Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan
The aim of the present study was to investigate the prevalence of submicroscopic infections and to assess its impact on maternal anaemia and low birth weight. A cross-sectional study was carried out with 1149 consented pregnant women who delivered at 3 main hospitals in the Blue Nile State, between...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3162378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414031405744128 |
|---|---|
| author | Samia A. Omer Ali N. Noureldein Hadeel Eisa Mutasim Abdelrahim Hagir E. Idress Abdelrahim M. Abdelrazig Ishag Adam |
| author_facet | Samia A. Omer Ali N. Noureldein Hadeel Eisa Mutasim Abdelrahim Hagir E. Idress Abdelrahim M. Abdelrazig Ishag Adam |
| author_sort | Samia A. Omer |
| collection | DOAJ |
| description | The aim of the present study was to investigate the prevalence of submicroscopic infections and to assess its impact on maternal anaemia and low birth weight. A cross-sectional study was carried out with 1149 consented pregnant women who delivered at 3 main hospitals in the Blue Nile State, between January 2012 and December 2015. From a matched maternal peripheral, placental maternal side, and cord blood sample, blood films and dried spots were prepared for microscopic examination and nested polymerase chain reaction (n-PCR), respectively. 107 out of 447 negative blood films were found to have submicroscopic infection detected using n-PCR in any of the three compartments. Placental samples had a significantly higher prevalence (142) of submicroscopic infections compared with the peripheral (6.5%) and cord (8.1%) samples. The mean (SD) of the maternal haemoglobin (Hb) was significantly lower in cases with submicroscopic parasitaemia (10.9 (0.8) vs. 12.1 (0.7) g/dl, P<0.001) compared with those who had no submicroscopic parasitaemia. Submicroscopic malaria infection was associated with anaemia (OR 19.7, (95% CI, 10.3–37.8)). Thirty-eight babies born to women with submicroscopic infections were low birth weight (LBW) and was significantly lower in submicroscopic parasitaemia (2.663 (0.235) vs. 2.926 (0.341) kg, P<0.001). Submicroscopic malaria infection was associated with LBW (OR = 2.7, (95% CI, 1.2–5.6)). There is a high incidence of submicroscopic infections in any of the three compartments regardless of age or parity. Submicroscopic infection is a risk of maternal anaemia and low birth weight in women in this area of high seasonal malaria transmission. |
| format | Article |
| id | doaj-art-7153e5ef63184ea180fe769b1f9ca0d3 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-7153e5ef63184ea180fe769b1f9ca0d32025-08-20T03:33:57ZengWileyJournal of Tropical Medicine1687-96861687-96942019-01-01201910.1155/2019/31623783162378Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, SudanSamia A. Omer0Ali N. Noureldein1Hadeel Eisa2Mutasim Abdelrahim3Hagir E. Idress4Abdelrahim M. Abdelrazig5Ishag Adam6Department of Immunology and Molecular Biology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, SudanFaculty of Medicine, University of Khartoum, Khartoum, SudanDepartment of Immunology and Molecular Biology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, SudanEd-Damazin Hospital, Blue Nile State Ministry of Health, Ed-Damazin, SudanSchool of Biomedical Sciences, Middlesex University, London, UKDepartment of Microbiology, Faculty of Medicine, Blue Nile University, Ad-Damazīn, SudanFaculty of Medicine, University of Khartoum, Khartoum, SudanThe aim of the present study was to investigate the prevalence of submicroscopic infections and to assess its impact on maternal anaemia and low birth weight. A cross-sectional study was carried out with 1149 consented pregnant women who delivered at 3 main hospitals in the Blue Nile State, between January 2012 and December 2015. From a matched maternal peripheral, placental maternal side, and cord blood sample, blood films and dried spots were prepared for microscopic examination and nested polymerase chain reaction (n-PCR), respectively. 107 out of 447 negative blood films were found to have submicroscopic infection detected using n-PCR in any of the three compartments. Placental samples had a significantly higher prevalence (142) of submicroscopic infections compared with the peripheral (6.5%) and cord (8.1%) samples. The mean (SD) of the maternal haemoglobin (Hb) was significantly lower in cases with submicroscopic parasitaemia (10.9 (0.8) vs. 12.1 (0.7) g/dl, P<0.001) compared with those who had no submicroscopic parasitaemia. Submicroscopic malaria infection was associated with anaemia (OR 19.7, (95% CI, 10.3–37.8)). Thirty-eight babies born to women with submicroscopic infections were low birth weight (LBW) and was significantly lower in submicroscopic parasitaemia (2.663 (0.235) vs. 2.926 (0.341) kg, P<0.001). Submicroscopic malaria infection was associated with LBW (OR = 2.7, (95% CI, 1.2–5.6)). There is a high incidence of submicroscopic infections in any of the three compartments regardless of age or parity. Submicroscopic infection is a risk of maternal anaemia and low birth weight in women in this area of high seasonal malaria transmission.http://dx.doi.org/10.1155/2019/3162378 |
| spellingShingle | Samia A. Omer Ali N. Noureldein Hadeel Eisa Mutasim Abdelrahim Hagir E. Idress Abdelrahim M. Abdelrazig Ishag Adam Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan Journal of Tropical Medicine |
| title | Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan |
| title_full | Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan |
| title_fullStr | Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan |
| title_full_unstemmed | Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan |
| title_short | Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan |
| title_sort | impact of submicroscopic plasmodium falciparum parasitaemia on maternal anaemia and low birth weight in blue nile state sudan |
| url | http://dx.doi.org/10.1155/2019/3162378 |
| work_keys_str_mv | AT samiaaomer impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan AT alinnoureldein impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan AT hadeeleisa impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan AT mutasimabdelrahim impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan AT hagireidress impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan AT abdelrahimmabdelrazig impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan AT ishagadam impactofsubmicroscopicplasmodiumfalciparumparasitaemiaonmaternalanaemiaandlowbirthweightinbluenilestatesudan |