Low-grade systemic inflammation and peripheral airway function
Background Low-grade systemic inflammation is linked to abnormal spirometry. Impulse oscillometry (IOS) is sensitive in detecting peripheral airway dysfunction, but inflammation in relation to IOS is poorly studied. The objectives of the present study were to analyse associations between C-reactive...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2025-02-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/11/1/00674-2024.full |
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| author | Martin Färdig Suneela Zaigham Gunnar Engström Christer Janson Per Wollmer Andrei Malinovschi |
| author_facet | Martin Färdig Suneela Zaigham Gunnar Engström Christer Janson Per Wollmer Andrei Malinovschi |
| author_sort | Martin Färdig |
| collection | DOAJ |
| description | Background
Low-grade systemic inflammation is linked to abnormal spirometry. Impulse oscillometry (IOS) is sensitive in detecting peripheral airway dysfunction, but inflammation in relation to IOS is poorly studied. The objectives of the present study were to analyse associations between C-reactive protein (CRP), blood eosinophils (B-Eos), blood neutrophils (B-Neu), blood lymphocytes (B-Lym), blood leukocytes (B-Leu), blood monocytes (B-Mono) and IOS.
Methods
Blood biomarkers and IOS were assessed in 10 602 adults (aged 50–65 years) within the Swedish CardioPulmonary bioImage Study (SCAPIS). Upper tertiles for CRP (>1.80 mg·L−1), B-Eos (>0.20 109·L−1), B-Neu (>3.40 109·L−1), B-Lym (>2.00 109·L−1), B-Leu (>6.10 109·L−1) and B-Mono (>0.50 109·L−1) were analysed in relation to the following abnormal IOS indices: resistance at 5 Hz, resistance at 20 Hz, area of reactance, resonant frequency (>95th percentile) and reactance at 5 Hz (<5th percentile), based on healthy, never-smoking SCAPIS participants.
Results
Abnormal IOS was observed in 1715 (16.2%), of which 580 (33.8%) also had abnormal spirometry. Having several blood biomarkers in the upper tertile (1, 2–3 or 4–6 versus 0) was overall associated with abnormal IOS; adjusted odds ratios (OR) and 95% confidence intervals (CI) ranging from 1.19 (1.02–1.38) to 2.27 (1.79–2.89). Furthermore, having 2–3 or more blood biomarkers versus 0 in the upper tertile was overall linked to abnormal IOS in participants with normal spirometry; adjusted OR (95% CI) ranging from 1.43 (1.17–1.75) to 1.75 (1.29–2.38).
Conclusions
Low-grade systemic inflammation was related to abnormal IOS and appeared consistent even when participants had normal spirometry. |
| format | Article |
| id | doaj-art-7153a73a3bd049b4be2a5b42b8b7423d |
| institution | DOAJ |
| issn | 2312-0541 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-7153a73a3bd049b4be2a5b42b8b7423d2025-08-20T03:16:36ZengEuropean Respiratory SocietyERJ Open Research2312-05412025-02-0111110.1183/23120541.00674-202400674-2024Low-grade systemic inflammation and peripheral airway functionMartin Färdig0Suneela Zaigham1Gunnar Engström2Christer Janson3Per Wollmer4Andrei Malinovschi5 Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden Department of Clinical Sciences, Cardiovascular Epidemiology, Lund University, Lund, Sweden Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Lund University, Lund, Sweden Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden Background Low-grade systemic inflammation is linked to abnormal spirometry. Impulse oscillometry (IOS) is sensitive in detecting peripheral airway dysfunction, but inflammation in relation to IOS is poorly studied. The objectives of the present study were to analyse associations between C-reactive protein (CRP), blood eosinophils (B-Eos), blood neutrophils (B-Neu), blood lymphocytes (B-Lym), blood leukocytes (B-Leu), blood monocytes (B-Mono) and IOS. Methods Blood biomarkers and IOS were assessed in 10 602 adults (aged 50–65 years) within the Swedish CardioPulmonary bioImage Study (SCAPIS). Upper tertiles for CRP (>1.80 mg·L−1), B-Eos (>0.20 109·L−1), B-Neu (>3.40 109·L−1), B-Lym (>2.00 109·L−1), B-Leu (>6.10 109·L−1) and B-Mono (>0.50 109·L−1) were analysed in relation to the following abnormal IOS indices: resistance at 5 Hz, resistance at 20 Hz, area of reactance, resonant frequency (>95th percentile) and reactance at 5 Hz (<5th percentile), based on healthy, never-smoking SCAPIS participants. Results Abnormal IOS was observed in 1715 (16.2%), of which 580 (33.8%) also had abnormal spirometry. Having several blood biomarkers in the upper tertile (1, 2–3 or 4–6 versus 0) was overall associated with abnormal IOS; adjusted odds ratios (OR) and 95% confidence intervals (CI) ranging from 1.19 (1.02–1.38) to 2.27 (1.79–2.89). Furthermore, having 2–3 or more blood biomarkers versus 0 in the upper tertile was overall linked to abnormal IOS in participants with normal spirometry; adjusted OR (95% CI) ranging from 1.43 (1.17–1.75) to 1.75 (1.29–2.38). Conclusions Low-grade systemic inflammation was related to abnormal IOS and appeared consistent even when participants had normal spirometry.http://openres.ersjournals.com/content/11/1/00674-2024.full |
| spellingShingle | Martin Färdig Suneela Zaigham Gunnar Engström Christer Janson Per Wollmer Andrei Malinovschi Low-grade systemic inflammation and peripheral airway function ERJ Open Research |
| title | Low-grade systemic inflammation and peripheral airway function |
| title_full | Low-grade systemic inflammation and peripheral airway function |
| title_fullStr | Low-grade systemic inflammation and peripheral airway function |
| title_full_unstemmed | Low-grade systemic inflammation and peripheral airway function |
| title_short | Low-grade systemic inflammation and peripheral airway function |
| title_sort | low grade systemic inflammation and peripheral airway function |
| url | http://openres.ersjournals.com/content/11/1/00674-2024.full |
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