Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria)
Introduction-The objectives of our work are to measure the incidence of thrombosis and identify predictive factors during the procedure of autologous hematopoietic stem cells, during real life, in the University Hospital of Oran (Algeria). Methods-This is a retrospective study covering a period fro...
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University of Oran 1
2022-06-01
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| Series: | Journal de la Faculté de Médecine d'Oran |
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| Online Access: | https://www.Ajol.Info/index.php/jfmo/article/view/227385 |
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| author | Mohammed Amine BEKADJA Brahim BENZINEB Mansour BELKACEM Hafida OUDJERIOUAT Badra ENTASOLTAN Soufi OSMANI Kamila AMANI Samira BOUCHAMA Leila CHAREF Mohamed BRAHIMI Abdessamad ARABI Rachir Amar BOUHASS Nabil YAFOUR |
| author_facet | Mohammed Amine BEKADJA Brahim BENZINEB Mansour BELKACEM Hafida OUDJERIOUAT Badra ENTASOLTAN Soufi OSMANI Kamila AMANI Samira BOUCHAMA Leila CHAREF Mohamed BRAHIMI Abdessamad ARABI Rachir Amar BOUHASS Nabil YAFOUR |
| author_sort | Mohammed Amine BEKADJA |
| collection | DOAJ |
| description |
Introduction-The objectives of our work are to measure the incidence of thrombosis
and identify predictive factors during the procedure of autologous hematopoietic
stem cells, during real life, in the University Hospital of Oran (Algeria).
Methods-This is a retrospective study covering a period from 2009 to 2019. The diagnosis
of thrombosis is made on the basis of clinical signs and symptoms of thrombosis
and confirmed by a Doppler ultrasound of the site of location concerned or
an angio-scanner, in the case of suspicion of arterial embolism, as well as D-Dimer
elevation. The study focused on the overall incidence of thrombosis and the identification
of predictive factors during the autograft procedure. Thepredictive factors
studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing
factor in mobilization, the central venous catheter insertion site, cytapheresis
count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low
molecular weight heparin .The statistical analysis focused on a univariate study,
followed by a multivariate analysis using binary logistic regression.
Results-Among 411 patients with MM underwent autologous transplantation of
which 249 were male with a sex ratio of 1,53. The overall incidence of thrombosis
was estimated at 18,49% (76 patients). The associative factors found in univariate
analysis in our study are the use of IMiDs (p = 0,0006), the femoral KTC insertion site
(p = 0,021) and its duration (p = 0,018), the level of G-CSG≥ 15μg/kg (0,014) during
HSC mobilization and aplastic phase, the number of perfused CD34 +> 5x106/kg (p
= 0,035) and prophylaxis with low molecular weight heparin (LMWH)(p = 0,029).In
multivariate analysis, only the absence of LMWH prophylaxis was an independent
predictor of thrombosis (p=0.001).
Conclusion-Despite the similarity of the overall incidence of thrombosis with the literature,
its prophylaxis with LMWHs was the only independent factor of its risk in
Algeria, which would have restricted it in daily practice of autografts in multiple
myeloma.
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| format | Article |
| id | doaj-art-7153805744a446e0a1b6df15a6f85757 |
| institution | Kabale University |
| issn | 2571-9874 2602-6511 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | University of Oran 1 |
| record_format | Article |
| series | Journal de la Faculté de Médecine d'Oran |
| spelling | doaj-art-7153805744a446e0a1b6df15a6f857572025-02-08T19:51:15ZengUniversity of Oran 1Journal de la Faculté de Médecine d'Oran2571-98742602-65112022-06-0161Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria)Mohammed Amine BEKADJA0Brahim BENZINEB1Mansour BELKACEM2Hafida OUDJERIOUAT3Badra ENTASOLTAN4Soufi OSMANI5Kamila AMANI6Samira BOUCHAMA7Leila CHAREF8Mohamed BRAHIMI9Abdessamad ARABI10Rachir Amar BOUHASS11Nabil YAFOUR12Service d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, Algérieservice d'Hématologie du CHU de Tlemcen, Université Abou Bakr BELKAID de TlemcenService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, AlgérieService d’Hématologie et de Thérapie Cellulaire, EHU 1er Novembre, Oran, Université Oran 1, Algérie Introduction-The objectives of our work are to measure the incidence of thrombosis and identify predictive factors during the procedure of autologous hematopoietic stem cells, during real life, in the University Hospital of Oran (Algeria). Methods-This is a retrospective study covering a period from 2009 to 2019. The diagnosis of thrombosis is made on the basis of clinical signs and symptoms of thrombosis and confirmed by a Doppler ultrasound of the site of location concerned or an angio-scanner, in the case of suspicion of arterial embolism, as well as D-Dimer elevation. The study focused on the overall incidence of thrombosis and the identification of predictive factors during the autograft procedure. Thepredictive factors studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing factor in mobilization, the central venous catheter insertion site, cytapheresis count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low molecular weight heparin .The statistical analysis focused on a univariate study, followed by a multivariate analysis using binary logistic regression. Results-Among 411 patients with MM underwent autologous transplantation of which 249 were male with a sex ratio of 1,53. The overall incidence of thrombosis was estimated at 18,49% (76 patients). The associative factors found in univariate analysis in our study are the use of IMiDs (p = 0,0006), the femoral KTC insertion site (p = 0,021) and its duration (p = 0,018), the level of G-CSG≥ 15μg/kg (0,014) during HSC mobilization and aplastic phase, the number of perfused CD34 +> 5x106/kg (p = 0,035) and prophylaxis with low molecular weight heparin (LMWH)(p = 0,029).In multivariate analysis, only the absence of LMWH prophylaxis was an independent predictor of thrombosis (p=0.001). Conclusion-Despite the similarity of the overall incidence of thrombosis with the literature, its prophylaxis with LMWHs was the only independent factor of its risk in Algeria, which would have restricted it in daily practice of autografts in multiple myeloma. https://www.Ajol.Info/index.php/jfmo/article/view/227385Autologous stem cellmultiple myelomapredictive factorsthrombosisLMWH |
| spellingShingle | Mohammed Amine BEKADJA Brahim BENZINEB Mansour BELKACEM Hafida OUDJERIOUAT Badra ENTASOLTAN Soufi OSMANI Kamila AMANI Samira BOUCHAMA Leila CHAREF Mohamed BRAHIMI Abdessamad ARABI Rachir Amar BOUHASS Nabil YAFOUR Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) Journal de la Faculté de Médecine d'Oran Autologous stem cell multiple myeloma predictive factors thrombosis LMWH |
| title | Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) |
| title_full | Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) |
| title_fullStr | Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) |
| title_full_unstemmed | Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) |
| title_short | Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) |
| title_sort | predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma experience from ehu oran algeria |
| topic | Autologous stem cell multiple myeloma predictive factors thrombosis LMWH |
| url | https://www.Ajol.Info/index.php/jfmo/article/view/227385 |
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