Biosynthesis of lactacystin as a proteasome inhibitor

Biosynthesis of lactacystin as a proteasome inhibitor

Abstract Lactacystin is an irreversible proteasome inhibitor isolated from Streptomyces lactacystinicus. Despite its importance for its biological activity, the biosynthesis of lactacystin remains unknown. In this study, we identified the lactacystin biosynthetic gene cluster by gene disruption and...

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Main Authors: Takeshi Tsunoda, Shunkichi Furumura, Haruka Yamazaki, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01406-4
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