Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study
Background: Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. It is the most common of the superficial fungal infections. Nowadays, these fungal infections are at a rise and run a prolonged course despite of treatment due to resis...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2021-04-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://www.nepjol.info/index.php/NJDVL/article/view/34693 |
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| author | Manish Bhakta Pradhan Vikash Paudel |
| author_facet | Manish Bhakta Pradhan Vikash Paudel |
| author_sort | Manish Bhakta Pradhan |
| collection | DOAJ |
| description |
Background: Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. It is the most common of the superficial fungal infections. Nowadays, these fungal infections are at a rise and run a prolonged course despite of treatment due to resistance to conventional antifungal agents. There is a felt need to conduct an epidemiological studies to know the change in the pattern and causes of widespread resistance.
Objectives: This study was aimed at identifying clinico-mycological patterns of dermatophytic infections in patients attending the dermatology outpatient department of a tertiary care hospital in Birgunj and the adjoining areas.
Methods: The study included cases of clinically diagnosed dermatophytosis from the outpatient department of Dermatology of National Medical College, Birgunj. Clinical and epidemiological data were collected as per proforma and skin scraping, hair plucking, and nail clipping were done and materials were examined microscopically by KOH mount then cultured on Sabouraud dextrose agar and antifungal susceptibility were done by disk diffusion test.
Results: here were 349 patients recruited in the study, with a male: female ratio of 1.6:1. The most commonly affected age group was 20–29 years (27.3%). Tinea corporis was the most common type observed (38.1%). Potassium hydroxide positivity was seen in 228 samples (65.3%) and culture positivity was found in 202 samples (57.9%). The most common species identified was Trichophyton rubrum (55%). The most sensitive drug was itraconazole, and more number of resistances was noted with fluconazole.
Conclusion: Dermatophytic infection is ecumenical in distribution with increased frequency in tropical and subtropical countries with variable epidemiology. Inadequate and irregular use of antifungal drugs has led to the emergence of resistant strains, which cause poor treatment outcomes. Thus, it is essential to test for antifungal sensitivity to check for resistance to antifungals.
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| format | Article |
| id | doaj-art-714fb3f5e9ec42f0b96aea07ea6f7246 |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-714fb3f5e9ec42f0b96aea07ea6f72462025-08-23T10:04:15ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2021-04-0119110.3126/njdvl.v19i1.34693Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based StudyManish Bhakta Pradhan0https://orcid.org/0000-0001-5220-6113Vikash Paudel1https://orcid.org/0000-0001-8729-052XNational Medical College, Birgunj, NepalNational Medical College, Birgunj, Nepal Background: Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. It is the most common of the superficial fungal infections. Nowadays, these fungal infections are at a rise and run a prolonged course despite of treatment due to resistance to conventional antifungal agents. There is a felt need to conduct an epidemiological studies to know the change in the pattern and causes of widespread resistance. Objectives: This study was aimed at identifying clinico-mycological patterns of dermatophytic infections in patients attending the dermatology outpatient department of a tertiary care hospital in Birgunj and the adjoining areas. Methods: The study included cases of clinically diagnosed dermatophytosis from the outpatient department of Dermatology of National Medical College, Birgunj. Clinical and epidemiological data were collected as per proforma and skin scraping, hair plucking, and nail clipping were done and materials were examined microscopically by KOH mount then cultured on Sabouraud dextrose agar and antifungal susceptibility were done by disk diffusion test. Results: here were 349 patients recruited in the study, with a male: female ratio of 1.6:1. The most commonly affected age group was 20–29 years (27.3%). Tinea corporis was the most common type observed (38.1%). Potassium hydroxide positivity was seen in 228 samples (65.3%) and culture positivity was found in 202 samples (57.9%). The most common species identified was Trichophyton rubrum (55%). The most sensitive drug was itraconazole, and more number of resistances was noted with fluconazole. Conclusion: Dermatophytic infection is ecumenical in distribution with increased frequency in tropical and subtropical countries with variable epidemiology. Inadequate and irregular use of antifungal drugs has led to the emergence of resistant strains, which cause poor treatment outcomes. Thus, it is essential to test for antifungal sensitivity to check for resistance to antifungals. https://www.nepjol.info/index.php/NJDVL/article/view/34693DermatophyteDermatophytosisTineaTrichophytonAntifungal susceptibility |
| spellingShingle | Manish Bhakta Pradhan Vikash Paudel Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study Nepal Journal of Dermatology, Venereology & Leprology Dermatophyte Dermatophytosis Tinea Trichophyton Antifungal susceptibility |
| title | Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study |
| title_full | Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study |
| title_fullStr | Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study |
| title_full_unstemmed | Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study |
| title_short | Clinico-mycological Study of Dermatophytosis and Their Antifungal Susceptibility, A Hospital Based Study |
| title_sort | clinico mycological study of dermatophytosis and their antifungal susceptibility a hospital based study |
| topic | Dermatophyte Dermatophytosis Tinea Trichophyton Antifungal susceptibility |
| url | https://www.nepjol.info/index.php/NJDVL/article/view/34693 |
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