Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study
Background Attention-deficit/hyperactivity disorder (ADHD) symptomatology in childhood is associated with a high risk of suicide attempt later in life. However, symptom presentation in ADHD is heterogeneous, and little is known about how suicide risk varies according to different profiles of ADHD sy...
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BMJ Publishing Group
2025-07-01
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| Series: | BMJ Mental Health |
| Online Access: | https://mentalhealth.bmj.com/content/28/1/e301725.full |
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| author | Samuele Cortese Cédric Galéra Marie-Claude Geoffroy Gustavo Turecki Richard E Tremblay Ayla Inja Sylvana M Côté Michel Spodenkiewicz Isabelle Ouellet-Morin Michel Boivin Frank Vitaro Mara Brendgen Ginette Dionne Johanne Renaud Massimilano Orri |
| author_facet | Samuele Cortese Cédric Galéra Marie-Claude Geoffroy Gustavo Turecki Richard E Tremblay Ayla Inja Sylvana M Côté Michel Spodenkiewicz Isabelle Ouellet-Morin Michel Boivin Frank Vitaro Mara Brendgen Ginette Dionne Johanne Renaud Massimilano Orri |
| author_sort | Samuele Cortese |
| collection | DOAJ |
| description | Background Attention-deficit/hyperactivity disorder (ADHD) symptomatology in childhood is associated with a high risk of suicide attempt later in life. However, symptom presentation in ADHD is heterogeneous, and little is known about how suicide risk varies according to different profiles of ADHD symptoms and sex.Objective The aim was to investigate the longitudinal associations between childhood profiles of ADHD symptoms (ie, hyperactivity–impulsivity and inattention) and youth suicide attempt in males and females, separately.Methods This population-based cohort study used data from three longitudinal cohorts: the Quebec Longitudinal Study of Child Development (QLSCD), the Quebec Longitudinal Study of Kindergarten Children (QLSKC) and the Quebec Newborn Twin Study (QNTS) for a total of 4399 participants (1490 from the QLSCD, 2134 from the QLSKC and 775 from the QNTS; 50% females) followed up from ages 6–23 years. Symptoms of hyperactivity–impulsivity and inattention were assessed by teachers five times from ages 6–12 years. Suicide attempt in adolescence and young adulthood (by age 23) was self-reported. Multitrajectory modelling was used to identify profiles of ADHD symptoms, and regression analysis was used to test their association with suicide attempt, adjusting for childhood socioeconomic and clinical characteristics.Findings We identified four ADHD symptom profiles with distinct associations with suicide attempt for males and females. Compared with those with persistently low symptoms, females with persistently high inattention and hyperactivity–impulsivity (OR: 2.54, CI 1.39 to 4.63) or high inattention and low hyperactivity–impulsivity (OR: 1.81, CI 1.21 to 2.70) were at higher risk of suicide attempt, while, among males, only those with decreasing hyperactivity–impulsivity and inattention over time (OR: 2.23, CI 1.20 to 4.13) were at higher risk of suicide attempt.Conclusions Risk of suicide attempt in children with ADHD symptoms varies according to both symptom profile and sex, the highest risk being for females with high inattention symptoms (with or without hyperactivity), and males with decreasing symptoms.Clinical implications Taking into account differences in both sex and ADHD symptoms profile may be relevant to more accurately identify and manage suicide risk in individuals with high ADHD symptoms, though caution is needed when generalising our population-based findings to clinical populations. |
| format | Article |
| id | doaj-art-7146166f57484776b66d46ab48a67c32 |
| institution | Kabale University |
| issn | 2755-9734 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Mental Health |
| spelling | doaj-art-7146166f57484776b66d46ab48a67c322025-08-20T03:29:02ZengBMJ Publishing GroupBMJ Mental Health2755-97342025-07-0128110.1136/bmjment-2025-301725Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort studySamuele Cortese0Cédric Galéra1Marie-Claude Geoffroy2Gustavo Turecki3Richard E Tremblay4Ayla Inja5Sylvana M Côté6Michel Spodenkiewicz7Isabelle Ouellet-Morin8Michel Boivin9Frank Vitaro10Mara Brendgen11Ginette Dionne12Johanne Renaud13Massimilano Orri14Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UKINSERM, Bordeaux Population Health Center, Bordeaux II University, Talence, FranceDepartment of Epidemiology, Biostatistics, and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, CanadaCentre de recherche Azrieli, CHU Sainte-Justine, Montreal, Quebec, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, CanadaCentre de recherche Azrieli, CHU Sainte-Justine, Montreal, Quebec, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, CanadaDepartment of Criminology, Université de Montreal, Montreal, Quebec, CanadaSchool of Psychology, Laval University, Québec City, Quebec, CanadaCentre de recherche Azrieli, CHU Sainte-Justine, Montreal, Quebec, CanadaDepartment of Psychology, Université du Québec à Montréal, Montreal, Quebec, CanadaSchool of Psychology, Laval University, Québec City, Quebec, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, CanadaBackground Attention-deficit/hyperactivity disorder (ADHD) symptomatology in childhood is associated with a high risk of suicide attempt later in life. However, symptom presentation in ADHD is heterogeneous, and little is known about how suicide risk varies according to different profiles of ADHD symptoms and sex.Objective The aim was to investigate the longitudinal associations between childhood profiles of ADHD symptoms (ie, hyperactivity–impulsivity and inattention) and youth suicide attempt in males and females, separately.Methods This population-based cohort study used data from three longitudinal cohorts: the Quebec Longitudinal Study of Child Development (QLSCD), the Quebec Longitudinal Study of Kindergarten Children (QLSKC) and the Quebec Newborn Twin Study (QNTS) for a total of 4399 participants (1490 from the QLSCD, 2134 from the QLSKC and 775 from the QNTS; 50% females) followed up from ages 6–23 years. Symptoms of hyperactivity–impulsivity and inattention were assessed by teachers five times from ages 6–12 years. Suicide attempt in adolescence and young adulthood (by age 23) was self-reported. Multitrajectory modelling was used to identify profiles of ADHD symptoms, and regression analysis was used to test their association with suicide attempt, adjusting for childhood socioeconomic and clinical characteristics.Findings We identified four ADHD symptom profiles with distinct associations with suicide attempt for males and females. Compared with those with persistently low symptoms, females with persistently high inattention and hyperactivity–impulsivity (OR: 2.54, CI 1.39 to 4.63) or high inattention and low hyperactivity–impulsivity (OR: 1.81, CI 1.21 to 2.70) were at higher risk of suicide attempt, while, among males, only those with decreasing hyperactivity–impulsivity and inattention over time (OR: 2.23, CI 1.20 to 4.13) were at higher risk of suicide attempt.Conclusions Risk of suicide attempt in children with ADHD symptoms varies according to both symptom profile and sex, the highest risk being for females with high inattention symptoms (with or without hyperactivity), and males with decreasing symptoms.Clinical implications Taking into account differences in both sex and ADHD symptoms profile may be relevant to more accurately identify and manage suicide risk in individuals with high ADHD symptoms, though caution is needed when generalising our population-based findings to clinical populations.https://mentalhealth.bmj.com/content/28/1/e301725.full |
| spellingShingle | Samuele Cortese Cédric Galéra Marie-Claude Geoffroy Gustavo Turecki Richard E Tremblay Ayla Inja Sylvana M Côté Michel Spodenkiewicz Isabelle Ouellet-Morin Michel Boivin Frank Vitaro Mara Brendgen Ginette Dionne Johanne Renaud Massimilano Orri Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study BMJ Mental Health |
| title | Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study |
| title_full | Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study |
| title_fullStr | Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study |
| title_full_unstemmed | Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study |
| title_short | Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study |
| title_sort | association of hyperactivity impulsivity and inattention symptom profiles with suicide attempt an 18 year population based cohort study |
| url | https://mentalhealth.bmj.com/content/28/1/e301725.full |
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