Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol
Introduction Private sector provision of HIV treatment is increasing in low-income and middle-income countries (LMIC). However, there is limited documentation of its outcomes. This protocol reports a proposed systematic review that will synthesise clinical outcomes of private sector HIV treatment in...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-01-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/1/e031844.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850174569686499328 |
|---|---|
| author | Siyan Yi Gitau Mburu Ewemade Igbinedion Sin How Lim Aung Zayar Paing Stefan Elbe Grace W Mwai |
| author_facet | Siyan Yi Gitau Mburu Ewemade Igbinedion Sin How Lim Aung Zayar Paing Stefan Elbe Grace W Mwai |
| author_sort | Siyan Yi |
| collection | DOAJ |
| description | Introduction Private sector provision of HIV treatment is increasing in low-income and middle-income countries (LMIC). However, there is limited documentation of its outcomes. This protocol reports a proposed systematic review that will synthesise clinical outcomes of private sector HIV treatment in LMIC.Methods and analysis This review will be conducted in accordance with the preferred reporting items for systematic review and meta-analyses protocols. Primary outcomes will include: (1) proportion of eligible patients initiating antiretroviral therapy (ART); (2) proportion of those on ART with <1000 copies/mL; (3) rate of all-cause mortality among ART recipients. Secondary outcomes will include: (1) proportion receiving Pneumocystis jiroveci pneumonia prophylaxis; (2) proportion with >90% ART adherence (based on any measure reported); (3) proportion screened for non-communicable diseases (specifically cervical cancer, diabetes, hypertension and mental ill health); (iv) proportion screened for tuberculosis. A search of five electronic bibliographical databases (Embase, Medline, PsychINFO, Web of Science and CINAHL) and reference lists of included articles will be conducted to identify relevant articles reporting HIV clinical outcomes. Searches will be limited to LMIC. No age, publication date, study-design or language limits will be applied. Authors of relevant studies will be contacted for clarification. Two reviewers will independently screen citations and abstracts, identify full text articles for inclusion, extract data and appraise the quality and bias of included studies. Outcome data will be pooled to generate aggregative proportions of primary and secondary outcomes. Descriptive statistics and a narrative synthesis will be presented. Heterogeneity and sensitivity assessments will be conducted to aid interpretation of results.Ethics and dissemination The results of this review will be disseminated through a peer-reviewed scientific manuscript and at international scientific conferences. Results will inform quality improvement strategies, replication of identified good practices, potential policy changes, and future research.PROSPERO registration number CRD42016040053. |
| format | Article |
| id | doaj-art-7145ada287934da5b274b3444ccebee4 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7145ada287934da5b274b3444ccebee42025-08-20T02:19:38ZengBMJ Publishing GroupBMJ Open2044-60552020-01-0110110.1136/bmjopen-2019-031844Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocolSiyan Yi0Gitau Mburu1Ewemade Igbinedion2Sin How Lim3Aung Zayar Paing4Stefan Elbe5Grace W Mwai6KHANA Center for Population Health Research, Phnom Penh, CambodiaDepartment of Sexual and Reproductive Health and Research, UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneve, Switzerland3 Department of Community Health, Igbinedion University Teaching Hospital, Okada, Nigeria4 Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia5 Programs Department, Alliance Myanmar, Yangon, Myanmar1 Centre for Global Health Policy, University of Sussex, Brighton, East Sussex, UK9 Brighton and Sussex University Hospitals NHS Trust, Brighton, UKIntroduction Private sector provision of HIV treatment is increasing in low-income and middle-income countries (LMIC). However, there is limited documentation of its outcomes. This protocol reports a proposed systematic review that will synthesise clinical outcomes of private sector HIV treatment in LMIC.Methods and analysis This review will be conducted in accordance with the preferred reporting items for systematic review and meta-analyses protocols. Primary outcomes will include: (1) proportion of eligible patients initiating antiretroviral therapy (ART); (2) proportion of those on ART with <1000 copies/mL; (3) rate of all-cause mortality among ART recipients. Secondary outcomes will include: (1) proportion receiving Pneumocystis jiroveci pneumonia prophylaxis; (2) proportion with >90% ART adherence (based on any measure reported); (3) proportion screened for non-communicable diseases (specifically cervical cancer, diabetes, hypertension and mental ill health); (iv) proportion screened for tuberculosis. A search of five electronic bibliographical databases (Embase, Medline, PsychINFO, Web of Science and CINAHL) and reference lists of included articles will be conducted to identify relevant articles reporting HIV clinical outcomes. Searches will be limited to LMIC. No age, publication date, study-design or language limits will be applied. Authors of relevant studies will be contacted for clarification. Two reviewers will independently screen citations and abstracts, identify full text articles for inclusion, extract data and appraise the quality and bias of included studies. Outcome data will be pooled to generate aggregative proportions of primary and secondary outcomes. Descriptive statistics and a narrative synthesis will be presented. Heterogeneity and sensitivity assessments will be conducted to aid interpretation of results.Ethics and dissemination The results of this review will be disseminated through a peer-reviewed scientific manuscript and at international scientific conferences. Results will inform quality improvement strategies, replication of identified good practices, potential policy changes, and future research.PROSPERO registration number CRD42016040053.https://bmjopen.bmj.com/content/10/1/e031844.full |
| spellingShingle | Siyan Yi Gitau Mburu Ewemade Igbinedion Sin How Lim Aung Zayar Paing Stefan Elbe Grace W Mwai Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol BMJ Open |
| title | Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol |
| title_full | Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol |
| title_fullStr | Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol |
| title_full_unstemmed | Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol |
| title_short | Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol |
| title_sort | outcomes of hiv treatment from the private sector in low income and middle income countries a systematic review protocol |
| url | https://bmjopen.bmj.com/content/10/1/e031844.full |
| work_keys_str_mv | AT siyanyi outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol AT gitaumburu outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol AT ewemadeigbinedion outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol AT sinhowlim outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol AT aungzayarpaing outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol AT stefanelbe outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol AT gracewmwai outcomesofhivtreatmentfromtheprivatesectorinlowincomeandmiddleincomecountriesasystematicreviewprotocol |