Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transplant Patients

Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transplant Patients

ABSTRACT Vitronectin (VTN) is a potential non‐invasive biomarker for renal fibrosis, originally described in urinary extracellular vesicles (uEV) from kidney transplant patients (KTx). However, VTN's specific role in renal fibrosis is unclear, as it is involved in various physiological processe...

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Main Authors: Marta Clos‐Sansalvador, Sergio G. Garcia, Paula Rodríguez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Cristina Grange, Benedetta Bussolati, Marcella Franquesa, Javier Juega, Francesc E. Borràs
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of Extracellular Biology
Subjects:
fibrinolysis
proximity extension assay
renal fibrosis
TNF
urinary extracellular vesicles
vitronectin
Online Access:https://doi.org/10.1002/jex2.70056
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