Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding
Abstract Preeclampsia (PE) is a pregnancy-specific complication and there remains no effective treatment. Given the limitations on medication use during pregnancy, exploring natural, safe, and effective drugs for PE is worthwhile. We investigate the causal relationship between ferroptosis, inflammat...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07547-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585428978368512 |
|---|---|
| author | Meiting Shi Lu Sun Jiachun Wei Yao Shen Jian Wang Ping Zhang Xiaofeng Yang Yuzhen Ding Wanchang Yin Xinyao Lu Xuesong Yang Guang Wang Ruiman Li |
| author_facet | Meiting Shi Lu Sun Jiachun Wei Yao Shen Jian Wang Ping Zhang Xiaofeng Yang Yuzhen Ding Wanchang Yin Xinyao Lu Xuesong Yang Guang Wang Ruiman Li |
| author_sort | Meiting Shi |
| collection | DOAJ |
| description | Abstract Preeclampsia (PE) is a pregnancy-specific complication and there remains no effective treatment. Given the limitations on medication use during pregnancy, exploring natural, safe, and effective drugs for PE is worthwhile. We investigate the causal relationship between ferroptosis, inflammation, and PE, and determine the protective effects of quercetin (QCT), a representative compound that is classified as a flavanol, against endothelial dysfunction. Then, the target of QCT is predicted and verified. The prophylactic addition of a low dose of QCT rescues endothelial dysfunction, aiding in endothelial repair. Furthermore, QCT alleviates PE-like maternal manifestations and endothelial dysfunction in the placenta of the selective reduced uteroplacental perfusion (sRUPP) rat model through binding to the epidermal growth factor receptor (EGFR). The potential applications of QCT are expanded, offering the possibility of further development as a safe and effective preventive molecule for PE. |
| format | Article |
| id | doaj-art-7140a06469c1445e806fb3765d9e0540 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-7140a06469c1445e806fb3765d9e05402025-01-26T12:48:18ZengNature PortfolioCommunications Biology2399-36422025-01-018111510.1038/s42003-025-07547-5Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR bindingMeiting Shi0Lu Sun1Jiachun Wei2Yao Shen3Jian Wang4Ping Zhang5Xiaofeng Yang6Yuzhen Ding7Wanchang Yin8Xinyao Lu9Xuesong Yang10Guang Wang11Ruiman Li12Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityInternational Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityInternational Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan UniversityInternational Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Jinan UniversityAbstract Preeclampsia (PE) is a pregnancy-specific complication and there remains no effective treatment. Given the limitations on medication use during pregnancy, exploring natural, safe, and effective drugs for PE is worthwhile. We investigate the causal relationship between ferroptosis, inflammation, and PE, and determine the protective effects of quercetin (QCT), a representative compound that is classified as a flavanol, against endothelial dysfunction. Then, the target of QCT is predicted and verified. The prophylactic addition of a low dose of QCT rescues endothelial dysfunction, aiding in endothelial repair. Furthermore, QCT alleviates PE-like maternal manifestations and endothelial dysfunction in the placenta of the selective reduced uteroplacental perfusion (sRUPP) rat model through binding to the epidermal growth factor receptor (EGFR). The potential applications of QCT are expanded, offering the possibility of further development as a safe and effective preventive molecule for PE.https://doi.org/10.1038/s42003-025-07547-5 |
| spellingShingle | Meiting Shi Lu Sun Jiachun Wei Yao Shen Jian Wang Ping Zhang Xiaofeng Yang Yuzhen Ding Wanchang Yin Xinyao Lu Xuesong Yang Guang Wang Ruiman Li Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding Communications Biology |
| title | Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding |
| title_full | Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding |
| title_fullStr | Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding |
| title_full_unstemmed | Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding |
| title_short | Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding |
| title_sort | quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through egfr binding |
| url | https://doi.org/10.1038/s42003-025-07547-5 |
| work_keys_str_mv | AT meitingshi quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT lusun quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT jiachunwei quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT yaoshen quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT jianwang quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT pingzhang quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT xiaofengyang quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT yuzhending quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT wanchangyin quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT xinyaolu quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT xuesongyang quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT guangwang quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding AT ruimanli quercetinalleviatesendothelialdysfunctioninpreeclampsiabyinhibitingferroptosisandinflammationthroughegfrbinding |