An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the chemotherapy-resistant ESCC features

Abstract Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with a poor prognosis and a high recurrence rate after chemotherapy, posing a significant clinical challenge. To elucidate the molecular basis of chemotherapy (chemo)-resistance and to develop methods to effectively eliminate chem...

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Bibliographic Details
Main Authors: Shunsaku Nakagawa, Taku Sato, Eriko Ohashi, Mihoko Kajita, Fuyuki Miya, Kouhei Yamamoto, Hiroki Yotsumata, Kazuya Yamaguchi, Yasuaki Nakajima, Akinori Miura, Yusuke Kinugasa, Toshiaki Ohteki
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07869-4
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