Differentiation-associated ISG expression of NK cells in chronic viral infection

Differentiation-associated ISG expression of NK cells in chronic viral infection

Summary: Natural killer (NK) cell responses are modulated by type-I interferons (IFNs) in viral infection. Chronic hepatitis C virus (HCV) infection, marked by robust IFN signatures, shows NK cells with reduced cytokine release but heightened cytotoxicity. Comparable alterations occur in chronic hep...

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Main Authors: Franziska Keller, Robert Lorenz Chua, Timo Trefzer, Katharina Jechow, Liane Bauersfeld, Fabian Beier, Sagar, Özlem Sogukpinar, Giuseppe Rusignuolo, Marta Rizzi, Roland Eils, Andreas Pichlmair, Marco Binder, Bertram Bengsch, Christoph Neumann-Haefelin, Volker Lohmann, Tobias Boettler, Christian Conrad, Robert Thimme, Maike Hofmann
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Immunology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014774
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