Hepatitis E virus infection among blood donors in Hangzhou
[Objective] To investigate the infection and characteristics of hepatitis E virus among blood donors in Hangzhou. [Methods] A total of 5 075 blood samples of blood donors from Zhejiang Provincial Blood Center from September to November 2023 were collected, including 5 037 samples with normal ALT and...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-01-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.004&lang=en |
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| _version_ | 1832585133790593024 |
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| author | DU Ziyun DENG Wenjun WU Danxiao LIU Jinhui DONG Jie |
| author_facet | DU Ziyun DENG Wenjun WU Danxiao LIU Jinhui DONG Jie |
| author_sort | DU Ziyun |
| collection | DOAJ |
| description | [Objective] To investigate the infection and characteristics of hepatitis E virus among blood donors in Hangzhou. [Methods] A total of 5 075 blood samples of blood donors from Zhejiang Provincial Blood Center from September to November 2023 were collected, including 5 037 samples with normal ALT and 38 samples with elevated ALT (>50 U/L). Enzyme-linked immunosorbent assay (ELISA) was used to detect anti-HEV IgM, anti-HEV IgG and HEV-Ag. The Fisher test and Chi-square test were used to evaluate the difference in the reactivity rates of anti-HEV IgM and anti-HEV IgG among different levels of ALT. The distribution characteristics of HEV screening in blood donors were analyzed. Univariate and multivariate logistic regression were used to analyze the susceptibility factors of anti-HEV IgM and anti-HEV IgG seropositivity, and the anti-HEV IgM-reactive blood donors were followed up by telephone. [Results] The reactivity rates of anti-HEV IgM, anti-HEV IgG and HEV-Ag in 5 075 blood samples were 0.45%, 22.98% and 0%, respectively. There was no difference in the reactivity rates of anti-HEV IgM and anti-HEV IgG among different levels of ALT (P>0.05), and the results of univariate and multivariate logistic regression analysis showed that age was a risk factor for anti-HEV IgM and anti-HEV IgG reactivity in blood donors (P<0.05), while no difference in the reactivity rates of anti-HEV IgM and anti-HEV IgG among blood donors was noticed in gender, occupation and education level (P>0.05). [Conclusion] There is a potential risk of transfusion-transmitted HEV (TT-HEV) in Hangzhou, and a cost-effective HEV screening strategy needs to be established to continue regular HEV surveillance in Hangzhou to assess the risk of infection. |
| format | Article |
| id | doaj-art-712947d63174462486590565e7c4d64d |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-712947d63174462486590565e7c4d64d2025-01-27T01:46:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-01-01381192510.13303/j.cjbt.issn.1004-549x.2025.01.0041004-549X(2025)1-0019-07Hepatitis E virus infection among blood donors in HangzhouDU Ziyun0DENG Wenjun1WU Danxiao2LIU Jinhui3DONG Jie4Blood Center of Zhejiang Province, Hangzhou 310000, ChinaBlood Center of Zhejiang Province, Hangzhou 310000, ChinaBlood Center of Zhejiang Province, Hangzhou 310000, ChinaBlood Center of Zhejiang Province, Hangzhou 310000, ChinaBlood Center of Zhejiang Province, Hangzhou 310000, China[Objective] To investigate the infection and characteristics of hepatitis E virus among blood donors in Hangzhou. [Methods] A total of 5 075 blood samples of blood donors from Zhejiang Provincial Blood Center from September to November 2023 were collected, including 5 037 samples with normal ALT and 38 samples with elevated ALT (>50 U/L). Enzyme-linked immunosorbent assay (ELISA) was used to detect anti-HEV IgM, anti-HEV IgG and HEV-Ag. The Fisher test and Chi-square test were used to evaluate the difference in the reactivity rates of anti-HEV IgM and anti-HEV IgG among different levels of ALT. The distribution characteristics of HEV screening in blood donors were analyzed. Univariate and multivariate logistic regression were used to analyze the susceptibility factors of anti-HEV IgM and anti-HEV IgG seropositivity, and the anti-HEV IgM-reactive blood donors were followed up by telephone. [Results] The reactivity rates of anti-HEV IgM, anti-HEV IgG and HEV-Ag in 5 075 blood samples were 0.45%, 22.98% and 0%, respectively. There was no difference in the reactivity rates of anti-HEV IgM and anti-HEV IgG among different levels of ALT (P>0.05), and the results of univariate and multivariate logistic regression analysis showed that age was a risk factor for anti-HEV IgM and anti-HEV IgG reactivity in blood donors (P<0.05), while no difference in the reactivity rates of anti-HEV IgM and anti-HEV IgG among blood donors was noticed in gender, occupation and education level (P>0.05). [Conclusion] There is a potential risk of transfusion-transmitted HEV (TT-HEV) in Hangzhou, and a cost-effective HEV screening strategy needs to be established to continue regular HEV surveillance in Hangzhou to assess the risk of infection.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.004&lang=enhepatitis e virus (hev)blood donorsblood screening |
| spellingShingle | DU Ziyun DENG Wenjun WU Danxiao LIU Jinhui DONG Jie Hepatitis E virus infection among blood donors in Hangzhou Zhongguo shuxue zazhi hepatitis e virus (hev) blood donors blood screening |
| title | Hepatitis E virus infection among blood donors in Hangzhou |
| title_full | Hepatitis E virus infection among blood donors in Hangzhou |
| title_fullStr | Hepatitis E virus infection among blood donors in Hangzhou |
| title_full_unstemmed | Hepatitis E virus infection among blood donors in Hangzhou |
| title_short | Hepatitis E virus infection among blood donors in Hangzhou |
| title_sort | hepatitis e virus infection among blood donors in hangzhou |
| topic | hepatitis e virus (hev) blood donors blood screening |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.004&lang=en |
| work_keys_str_mv | AT duziyun hepatitisevirusinfectionamongblooddonorsinhangzhou AT dengwenjun hepatitisevirusinfectionamongblooddonorsinhangzhou AT wudanxiao hepatitisevirusinfectionamongblooddonorsinhangzhou AT liujinhui hepatitisevirusinfectionamongblooddonorsinhangzhou AT dongjie hepatitisevirusinfectionamongblooddonorsinhangzhou |