Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock

Abstract Temporary transvenous cardiac pacing (TTP) is commonly used to manage hemodynamically compromising, drug-refractory brady- and tachyarrhythmias in the intensive care setting. Despite previous studies analyzing TTP treatment, data on its use in patients with cardiogenic shock (CS) remain lim...

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Main Authors: Clemens Walter von Musil, Valentina Riederer, Leonhard Pilsbacher, Carina Maria Paulus, Severin Rudinger, Sophia Bodlee, Jonas Gmeiner, Julius Fischer, Julius Steffen, Sven Peterß, Stefan Kääb, Moritz Sinner, Korbinian Lackermair, Martin Orban, Steffen Massberg, Clemens Scherer
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-10364-9
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author Clemens Walter von Musil
Valentina Riederer
Leonhard Pilsbacher
Carina Maria Paulus
Severin Rudinger
Sophia Bodlee
Jonas Gmeiner
Julius Fischer
Julius Steffen
Sven Peterß
Stefan Kääb
Moritz Sinner
Korbinian Lackermair
Martin Orban
Steffen Massberg
Clemens Scherer
author_facet Clemens Walter von Musil
Valentina Riederer
Leonhard Pilsbacher
Carina Maria Paulus
Severin Rudinger
Sophia Bodlee
Jonas Gmeiner
Julius Fischer
Julius Steffen
Sven Peterß
Stefan Kääb
Moritz Sinner
Korbinian Lackermair
Martin Orban
Steffen Massberg
Clemens Scherer
author_sort Clemens Walter von Musil
collection DOAJ
description Abstract Temporary transvenous cardiac pacing (TTP) is commonly used to manage hemodynamically compromising, drug-refractory brady- and tachyarrhythmias in the intensive care setting. Despite previous studies analyzing TTP treatment, data on its use in patients with cardiogenic shock (CS) remain limited. This retrospective exploratory analysis aimed to investigate the utilization of TTP in patients experiencing CS, with a particular focus on treatment characteristics, complication rates, predictive factors, and outcomes across different subgroups. We retrospectively included registry data from 184 patients who underwent TTP therapy from 1561 cases of CS treated at the Intensive Care Units (ICUs) of two university hospitals in Germany between 2010 and 2023. Bradycardia due to acute myocardial infarction was the primary indication for TTP implantation in patients with CS. The median duration of TTP therapy was 65 h, during which complications occurred in 12.0% of cases, 3.3% were classified as severe. We found that culprit lesions in the Right Coronary Artery (RCA) were more likely to necessitate TTP treatment in patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) (OR 2.52, 95% CI 1.54–4.11, p < 0.001). In non-AMI-CS patients, age (OR 1.03, 95% CI 1.01–1.05, p < 0.005) and myocarditis (OR 3.21, 95% CI 1.19–8.64, p = 0.02) were associated with a higher incidence of TTP therapy during ICU treatment. Further studies are needed to validate these observations. Trial registration: LMUshock registry (WHO International Clinical Trials Registry Platform Number DRKS00015860).
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spelling doaj-art-71239afa4fcd43ac8ae23e0cdb0a8fbb2025-08-20T03:04:39ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-10364-9Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shockClemens Walter von Musil0Valentina Riederer1Leonhard Pilsbacher2Carina Maria Paulus3Severin Rudinger4Sophia Bodlee5Jonas Gmeiner6Julius Fischer7Julius Steffen8Sven Peterß9Stefan Kääb10Moritz Sinner11Korbinian Lackermair12Martin Orban13Steffen Massberg14Clemens Scherer15Department of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Cardiac Surgery, LMU University Hospital, LMU MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichDepartment of Medicine I, LMU University Hospital, Ludwig-Maximilians-University (LMU) MunichAbstract Temporary transvenous cardiac pacing (TTP) is commonly used to manage hemodynamically compromising, drug-refractory brady- and tachyarrhythmias in the intensive care setting. Despite previous studies analyzing TTP treatment, data on its use in patients with cardiogenic shock (CS) remain limited. This retrospective exploratory analysis aimed to investigate the utilization of TTP in patients experiencing CS, with a particular focus on treatment characteristics, complication rates, predictive factors, and outcomes across different subgroups. We retrospectively included registry data from 184 patients who underwent TTP therapy from 1561 cases of CS treated at the Intensive Care Units (ICUs) of two university hospitals in Germany between 2010 and 2023. Bradycardia due to acute myocardial infarction was the primary indication for TTP implantation in patients with CS. The median duration of TTP therapy was 65 h, during which complications occurred in 12.0% of cases, 3.3% were classified as severe. We found that culprit lesions in the Right Coronary Artery (RCA) were more likely to necessitate TTP treatment in patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) (OR 2.52, 95% CI 1.54–4.11, p < 0.001). In non-AMI-CS patients, age (OR 1.03, 95% CI 1.01–1.05, p < 0.005) and myocarditis (OR 3.21, 95% CI 1.19–8.64, p = 0.02) were associated with a higher incidence of TTP therapy during ICU treatment. Further studies are needed to validate these observations. Trial registration: LMUshock registry (WHO International Clinical Trials Registry Platform Number DRKS00015860).https://doi.org/10.1038/s41598-025-10364-9Cardiogenic shockAcute myocardial infarctionTemporary cardiac pacingIntensive careArrhythmia
spellingShingle Clemens Walter von Musil
Valentina Riederer
Leonhard Pilsbacher
Carina Maria Paulus
Severin Rudinger
Sophia Bodlee
Jonas Gmeiner
Julius Fischer
Julius Steffen
Sven Peterß
Stefan Kääb
Moritz Sinner
Korbinian Lackermair
Martin Orban
Steffen Massberg
Clemens Scherer
Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock
Scientific Reports
Cardiogenic shock
Acute myocardial infarction
Temporary cardiac pacing
Intensive care
Arrhythmia
title Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock
title_full Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock
title_fullStr Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock
title_full_unstemmed Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock
title_short Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock
title_sort retrospective exploratory dual center analysis of temporary transvenous cardiac pacing in cardiogenic shock
topic Cardiogenic shock
Acute myocardial infarction
Temporary cardiac pacing
Intensive care
Arrhythmia
url https://doi.org/10.1038/s41598-025-10364-9
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