RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study
Introduction: Brugada syndrome (BrS) is a cardiac ion channelopathy with a higher prevalence in Asia compared to the Western populations. The present study compared the differences in clinical and electrocardiographic (ECG) presentation between paediatric/young (≤25 years old) and adult (>25...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.671666/full |
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| author | Sharen Lee Wing Tak Wong Ian Chi Kei Wong Ian Chi Kei Wong Chloe Mak Ngai Shing Mok Tong Liu Gary Tse Gary Tse Gary Tse |
| author_facet | Sharen Lee Wing Tak Wong Ian Chi Kei Wong Ian Chi Kei Wong Chloe Mak Ngai Shing Mok Tong Liu Gary Tse Gary Tse Gary Tse |
| author_sort | Sharen Lee |
| collection | DOAJ |
| description | Introduction: Brugada syndrome (BrS) is a cardiac ion channelopathy with a higher prevalence in Asia compared to the Western populations. The present study compared the differences in clinical and electrocardiographic (ECG) presentation between paediatric/young (≤25 years old) and adult (>25 years) BrS patients.Method: This was a territory-wide retrospective cohort study of consecutive BrS patients presenting to public hospitals in Hong Kong. The primary outcome was spontaneous ventricular tachycardia/ventricular fibrillation (VT/VF).Results: The cohort consists of 550 consecutive patients (median age of initial presentation = 51 ± 23 years; female = 7.3%; follow-up period = 83 ± 80 months), divided into adult (n = 505, mean age of initial presentation = 52 ± 19 years; female = 6.7%; mean follow-up period = 83 ± 80 months) and paediatric/young subgroups (n = 45, mean age of initial presentation = 21 ± 5 years, female = 13.3%, mean follow-up period = 73 ± 83 months). The mean annual VT/VF incidence rate were 17 and 25 cases per 1,000 patient-year, respectively. Multivariate analysis showed that initial presentation of type 1 pattern (HR = 1.80, 95% CI = [1.02, 3.15], p = 0.041), initial asymptomatic presentation (HR = 0.26, 95% CI = [0.07, 0.94], p = 0.040) and increased P-wave axis (HR = 0.98, 95% CI = [0.96, 1.00], p = 0.036) were significant predictors of VT/VF for the adult subgroup. Only initial presentation of VT/VF was predictive (HR = 29.30, 95% CI = [1.75, 492.00], p = 0.019) in the paediatric/young subgroup.Conclusion: Clinical and ECG presentation of BrS vary between the paediatric/young and adult population in BrS. Risk stratification and management strategies for younger patients should take into consideration and adopt an individualised approach. |
| format | Article |
| id | doaj-art-71233981b4aa4a78be897fcd608138fb |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-71233981b4aa4a78be897fcd608138fb2025-08-20T01:52:48ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-06-01810.3389/fcvm.2021.671666671666RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide StudySharen Lee0Wing Tak Wong1Ian Chi Kei Wong2Ian Chi Kei Wong3Chloe Mak4Ngai Shing Mok5Tong Liu6Gary Tse7Gary Tse8Gary Tse9Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, Hong Kong, ChinaState Key Laboratory of Agrobiotechnology (CUHK), School of Life Sciences, Chinese University of Hong Kong, Hong Kong, ChinaCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Pharmacy, University College London, London, United KingdomDepartment of Pathology, Hong Kong Children's Hospital, Hong Kong, ChinaDepartment of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, ChinaTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, ChinaFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomKent and Medway Medical School, Canterbury, United KingdomIntroduction: Brugada syndrome (BrS) is a cardiac ion channelopathy with a higher prevalence in Asia compared to the Western populations. The present study compared the differences in clinical and electrocardiographic (ECG) presentation between paediatric/young (≤25 years old) and adult (>25 years) BrS patients.Method: This was a territory-wide retrospective cohort study of consecutive BrS patients presenting to public hospitals in Hong Kong. The primary outcome was spontaneous ventricular tachycardia/ventricular fibrillation (VT/VF).Results: The cohort consists of 550 consecutive patients (median age of initial presentation = 51 ± 23 years; female = 7.3%; follow-up period = 83 ± 80 months), divided into adult (n = 505, mean age of initial presentation = 52 ± 19 years; female = 6.7%; mean follow-up period = 83 ± 80 months) and paediatric/young subgroups (n = 45, mean age of initial presentation = 21 ± 5 years, female = 13.3%, mean follow-up period = 73 ± 83 months). The mean annual VT/VF incidence rate were 17 and 25 cases per 1,000 patient-year, respectively. Multivariate analysis showed that initial presentation of type 1 pattern (HR = 1.80, 95% CI = [1.02, 3.15], p = 0.041), initial asymptomatic presentation (HR = 0.26, 95% CI = [0.07, 0.94], p = 0.040) and increased P-wave axis (HR = 0.98, 95% CI = [0.96, 1.00], p = 0.036) were significant predictors of VT/VF for the adult subgroup. Only initial presentation of VT/VF was predictive (HR = 29.30, 95% CI = [1.75, 492.00], p = 0.019) in the paediatric/young subgroup.Conclusion: Clinical and ECG presentation of BrS vary between the paediatric/young and adult population in BrS. Risk stratification and management strategies for younger patients should take into consideration and adopt an individualised approach.https://www.frontiersin.org/articles/10.3389/fcvm.2021.671666/fullBrugada syndnromepaediatricrisk stratificationventricular arrhythmiasudden cardiac death |
| spellingShingle | Sharen Lee Wing Tak Wong Ian Chi Kei Wong Ian Chi Kei Wong Chloe Mak Ngai Shing Mok Tong Liu Gary Tse Gary Tse Gary Tse RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study Frontiers in Cardiovascular Medicine Brugada syndnrome paediatric risk stratification ventricular arrhythmia sudden cardiac death |
| title | RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study |
| title_full | RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study |
| title_fullStr | RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study |
| title_full_unstemmed | RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study |
| title_short | RETRACTED: Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study |
| title_sort | retracted ventricular tachyarrhythmia risk in paediatric young vs adult brugada syndrome patients a territory wide study |
| topic | Brugada syndnrome paediatric risk stratification ventricular arrhythmia sudden cardiac death |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.671666/full |
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