Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury
Objective To explore the relationship between lactate-to-albumin ratio (LAR) at ICU admission and prognosis in critically ill patients with acute kidney injury (AKI).Methods A retrospective analysis was conducted. Patients were divided into low (<0.659) LAR and high LAR (≥0.659) groups. Least abs...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2350238 |
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| author | Xiaoyun Shi Lei Zhong Jianhong Lu Beiping Hu Qikai Shen Penghui Gao |
| author_facet | Xiaoyun Shi Lei Zhong Jianhong Lu Beiping Hu Qikai Shen Penghui Gao |
| author_sort | Xiaoyun Shi |
| collection | DOAJ |
| description | Objective To explore the relationship between lactate-to-albumin ratio (LAR) at ICU admission and prognosis in critically ill patients with acute kidney injury (AKI).Methods A retrospective analysis was conducted. Patients were divided into low (<0.659) LAR and high LAR (≥0.659) groups. Least absolute shrinkage and selection operator regression analysis was conducted to select variables associated with the 30-day prognosis. Cox regression analyses were performed to assess the association between LAR and mortality. Kaplan-Meier curves were plotted to compare cumulative survival rates between high and low LAR groups. Subgroup analysis was employed to assess the stability of the results. ROC curve was used to determine the diagnostic efficacy of LAR on prognosis.Results A nonlinear relationship was observed between LAR and the risk of 30-day and 360-day all-cause mortality in AKI patients (p < 0.001). Cox regulation showed that high LAR (≥ 0.659) was an independent risk factor for 30-day and 360-day all-cause mortality in patients with AKI (p < 0.001). The Kaplan-Meier survival curves demonstrated a noteworthy decrease in cumulative survival rates at both 30 and 360 days for the high LAR group in comparison to the low LAR group (p < 0.001). Subgroup analyses demonstrated the stability of the results. ROC curves showed that LAR had a diagnostic advantage when compared with lactate or albumin alone (p < 0.001).Conclusion High LAR (≥0.659) at ICU admission was an independent risk factor for both short-term (30-day) and long-term (360-day) all-cause mortality in patients with AKI. |
| format | Article |
| id | doaj-art-711df89c3ec14d71a81181068873652c |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Renal Failure |
| spelling | doaj-art-711df89c3ec14d71a81181068873652c2025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2350238Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injuryXiaoyun Shi0Lei Zhong1Jianhong Lu2Beiping Hu3Qikai Shen4Penghui Gao5Department of Emergency, The Second Hospital of Shandong University, Jinan, ChinaDepartment of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, ChinaDepartment of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, ChinaDepartment of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, ChinaDepartment of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, ChinaDepartment of Emergency, The Second Hospital of Shandong University, Jinan, ChinaObjective To explore the relationship between lactate-to-albumin ratio (LAR) at ICU admission and prognosis in critically ill patients with acute kidney injury (AKI).Methods A retrospective analysis was conducted. Patients were divided into low (<0.659) LAR and high LAR (≥0.659) groups. Least absolute shrinkage and selection operator regression analysis was conducted to select variables associated with the 30-day prognosis. Cox regression analyses were performed to assess the association between LAR and mortality. Kaplan-Meier curves were plotted to compare cumulative survival rates between high and low LAR groups. Subgroup analysis was employed to assess the stability of the results. ROC curve was used to determine the diagnostic efficacy of LAR on prognosis.Results A nonlinear relationship was observed between LAR and the risk of 30-day and 360-day all-cause mortality in AKI patients (p < 0.001). Cox regulation showed that high LAR (≥ 0.659) was an independent risk factor for 30-day and 360-day all-cause mortality in patients with AKI (p < 0.001). The Kaplan-Meier survival curves demonstrated a noteworthy decrease in cumulative survival rates at both 30 and 360 days for the high LAR group in comparison to the low LAR group (p < 0.001). Subgroup analyses demonstrated the stability of the results. ROC curves showed that LAR had a diagnostic advantage when compared with lactate or albumin alone (p < 0.001).Conclusion High LAR (≥0.659) at ICU admission was an independent risk factor for both short-term (30-day) and long-term (360-day) all-cause mortality in patients with AKI.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2350238Lactate-to-albumin ratioacute kidney injurymedical information mart for intensive careintensive care unitprognosis |
| spellingShingle | Xiaoyun Shi Lei Zhong Jianhong Lu Beiping Hu Qikai Shen Penghui Gao Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury Renal Failure Lactate-to-albumin ratio acute kidney injury medical information mart for intensive care intensive care unit prognosis |
| title | Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury |
| title_full | Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury |
| title_fullStr | Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury |
| title_full_unstemmed | Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury |
| title_short | Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury |
| title_sort | clinical significance of the lactate to albumin ratio on prognosis in critically ill patients with acute kidney injury |
| topic | Lactate-to-albumin ratio acute kidney injury medical information mart for intensive care intensive care unit prognosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2350238 |
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