Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice
Tabebuia avellanedae has been traditionally used as an herbal remedy to alleviate various diseases. However, the plant’s pharmacological activity in allergic and inflammatory diseases and its underlying mechanism are not fully understood. Therefore, we investigated the pharmacological activity of Ta...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9079527 |
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| author | Jae Gwang Park Young-Su Yi Sang Yun Han Yo Han Hong Sulgi Yoo Eunji Kim Seong-Gu Jeong Adithan Aravinthan Kwang Soo Baik Su Young Choi Jung-Il Kim Young-Jin Son Jong-Hoon Kim Jae Youl Cho |
| author_facet | Jae Gwang Park Young-Su Yi Sang Yun Han Yo Han Hong Sulgi Yoo Eunji Kim Seong-Gu Jeong Adithan Aravinthan Kwang Soo Baik Su Young Choi Jung-Il Kim Young-Jin Son Jong-Hoon Kim Jae Youl Cho |
| author_sort | Jae Gwang Park |
| collection | DOAJ |
| description | Tabebuia avellanedae has been traditionally used as an herbal remedy to alleviate various diseases. However, the plant’s pharmacological activity in allergic and inflammatory diseases and its underlying mechanism are not fully understood. Therefore, we investigated the pharmacological activity of Tabetri (T. avellanedae ethanol extract (Ta-EE)) in the pathogenesis of AD. Its underlying mechanism was explored using an AD mouse model and splenocytes isolated from this model. Ta-EE ameliorated the AD symptoms without any toxicity and protected the skin of 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice from damage and epidermal thickness. Ta-EE reduced the secreted levels of allergic and proinflammatory cytokines, including histamine, immunoglobulin E (IgE), interleukin- (IL-) 4, and interferon-gamma (IFN-γ) in the DNCB-induced AD mice. Ta-EE suppressed the mRNA expression of T helper 2-specific cytokines, IL-4 and IL-5, and the proinflammatory cytokine IFN-γ in the atopic dermatitis skin lesions of AD mice. Moreover, Ta-EE suppressed the mRNA expression of IL-4, IL-5, IFN-γ, and another proinflammatory cytokine, IL-12, in the Con A-stimulated splenocytes. It also suppressed IL-12 and IFN-γ in the LPS-stimulated splenocytes. Taken together, these results suggest that Ta-EE protects against the development of AD through the inhibition of mRNA expression of T helper 2-specific cytokines and other proinflammatory cytokines. |
| format | Article |
| id | doaj-art-711badc3cf7f40f88c199462f3c1c6cf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-711badc3cf7f40f88c199462f3c1c6cf2025-08-20T03:33:57ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/90795279079527Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in MiceJae Gwang Park0Young-Su Yi1Sang Yun Han2Yo Han Hong3Sulgi Yoo4Eunji Kim5Seong-Gu Jeong6Adithan Aravinthan7Kwang Soo Baik8Su Young Choi9Jung-Il Kim10Young-Jin Son11Jong-Hoon Kim12Jae Youl Cho13Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaDepartment of Pharmaceutical Engineering, Cheongju University, Cheongju 28503, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaCollege of Veterinary Medicine, Chonbuk National University, Iksan 54596, Republic of KoreaR&I Planning Department, Nutribiotech Co. Ltd., Seoul 06132, Republic of KoreaR&I Planning Department, Nutribiotech Co. Ltd., Seoul 06132, Republic of KoreaDepartment of Information Statistics, Kangwon National University, Chuncheon 24341, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 57922, Republic of KoreaCollege of Veterinary Medicine, Chonbuk National University, Iksan 54596, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of KoreaTabebuia avellanedae has been traditionally used as an herbal remedy to alleviate various diseases. However, the plant’s pharmacological activity in allergic and inflammatory diseases and its underlying mechanism are not fully understood. Therefore, we investigated the pharmacological activity of Tabetri (T. avellanedae ethanol extract (Ta-EE)) in the pathogenesis of AD. Its underlying mechanism was explored using an AD mouse model and splenocytes isolated from this model. Ta-EE ameliorated the AD symptoms without any toxicity and protected the skin of 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice from damage and epidermal thickness. Ta-EE reduced the secreted levels of allergic and proinflammatory cytokines, including histamine, immunoglobulin E (IgE), interleukin- (IL-) 4, and interferon-gamma (IFN-γ) in the DNCB-induced AD mice. Ta-EE suppressed the mRNA expression of T helper 2-specific cytokines, IL-4 and IL-5, and the proinflammatory cytokine IFN-γ in the atopic dermatitis skin lesions of AD mice. Moreover, Ta-EE suppressed the mRNA expression of IL-4, IL-5, IFN-γ, and another proinflammatory cytokine, IL-12, in the Con A-stimulated splenocytes. It also suppressed IL-12 and IFN-γ in the LPS-stimulated splenocytes. Taken together, these results suggest that Ta-EE protects against the development of AD through the inhibition of mRNA expression of T helper 2-specific cytokines and other proinflammatory cytokines.http://dx.doi.org/10.1155/2018/9079527 |
| spellingShingle | Jae Gwang Park Young-Su Yi Sang Yun Han Yo Han Hong Sulgi Yoo Eunji Kim Seong-Gu Jeong Adithan Aravinthan Kwang Soo Baik Su Young Choi Jung-Il Kim Young-Jin Son Jong-Hoon Kim Jae Youl Cho Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice Mediators of Inflammation |
| title | Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice |
| title_full | Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice |
| title_fullStr | Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice |
| title_full_unstemmed | Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice |
| title_short | Tabetri™ (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice |
| title_sort | tabetri™ tabebuia avellanedae ethanol extract ameliorates atopic dermatitis symptoms in mice |
| url | http://dx.doi.org/10.1155/2018/9079527 |
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