Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer
Breast cancer (BRCA) has severely threatened women’s health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic eff...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/9005073 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850221126600359936 |
|---|---|
| author | Zhifeng Li Fujin Wang Yinxing Zhu Ting Guo Mei Lin |
| author_facet | Zhifeng Li Fujin Wang Yinxing Zhu Ting Guo Mei Lin |
| author_sort | Zhifeng Li |
| collection | DOAJ |
| description | Breast cancer (BRCA) has severely threatened women’s health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic efficacy of radiotherapy. Long noncoding RNAs (lncRNAs) are suggested to dominate crucial roles in regulating the biological behavior of BRCA. Currently, some studies indicate that overexpression or inhibition of lncRNAs can greatly alter the radioresistance of BRCA. In this review, we summarized the knowledge on the classification and function of lncRNAs and the molecular mechanism of BRCA radioresistance, listed lncRNAs related to the BRCA radioresistance, highlighted their underlying mechanisms, and discussed the potential application of these lncRNAs in regulating BRCA radioresistance. |
| format | Article |
| id | doaj-art-710faa723cc748d88dd1d9c8e79df7c4 |
| institution | OA Journals |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-710faa723cc748d88dd1d9c8e79df7c42025-08-20T02:06:47ZengWileyAnalytical Cellular Pathology2210-71772210-71852021-01-01202110.1155/2021/90050739005073Long Noncoding RNAs Regulate the Radioresistance of Breast CancerZhifeng Li0Fujin Wang1Yinxing Zhu2Ting Guo3Mei Lin4Department of Oncology, Medical College of Nantong University, Nantong, 226001 Jiangsu, ChinaDepartment of Radiology, The First People's Hospital of Yancheng, Yancheng, 224006 Jiangsu, ChinaTaizhou People’s Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou, 225300 Jiangsu Province, ChinaResearch Center of Clinical Medicine, Taizhou People’s Hospital (the Affiliated Hospital 5 of Nantong University), Taizhou, 225300 Jiangsu Province, ChinaResearch Center of Clinical Medicine, Taizhou People’s Hospital (the Affiliated Hospital 5 of Nantong University), Taizhou, 225300 Jiangsu Province, ChinaBreast cancer (BRCA) has severely threatened women’s health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic efficacy of radiotherapy. Long noncoding RNAs (lncRNAs) are suggested to dominate crucial roles in regulating the biological behavior of BRCA. Currently, some studies indicate that overexpression or inhibition of lncRNAs can greatly alter the radioresistance of BRCA. In this review, we summarized the knowledge on the classification and function of lncRNAs and the molecular mechanism of BRCA radioresistance, listed lncRNAs related to the BRCA radioresistance, highlighted their underlying mechanisms, and discussed the potential application of these lncRNAs in regulating BRCA radioresistance.http://dx.doi.org/10.1155/2021/9005073 |
| spellingShingle | Zhifeng Li Fujin Wang Yinxing Zhu Ting Guo Mei Lin Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer Analytical Cellular Pathology |
| title | Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer |
| title_full | Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer |
| title_fullStr | Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer |
| title_full_unstemmed | Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer |
| title_short | Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer |
| title_sort | long noncoding rnas regulate the radioresistance of breast cancer |
| url | http://dx.doi.org/10.1155/2021/9005073 |
| work_keys_str_mv | AT zhifengli longnoncodingrnasregulatetheradioresistanceofbreastcancer AT fujinwang longnoncodingrnasregulatetheradioresistanceofbreastcancer AT yinxingzhu longnoncodingrnasregulatetheradioresistanceofbreastcancer AT tingguo longnoncodingrnasregulatetheradioresistanceofbreastcancer AT meilin longnoncodingrnasregulatetheradioresistanceofbreastcancer |