Microbial lipid-based biodiesel production using wastewater: opportunities and challenges

Abstract Rising environmental concerns and fossil fuel depletion necessitate the search for sustainable, alternative energy sources. Biodiesel is emerging as a viable alternative owing to its biodegradability, low toxicity, and reduced greenhouse gas emissions. This review highlights the environment...

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Main Authors: Ameera Al Shehhi, Yasmine Souissi, Anu Sadasivan Nair, Zeba Usmani, Minaxi Sharma, Nallusamy Sivakumar
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Bioresources and Bioprocessing
Subjects:
Online Access:https://doi.org/10.1186/s40643-025-00897-2
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author Ameera Al Shehhi
Yasmine Souissi
Anu Sadasivan Nair
Zeba Usmani
Minaxi Sharma
Nallusamy Sivakumar
author_facet Ameera Al Shehhi
Yasmine Souissi
Anu Sadasivan Nair
Zeba Usmani
Minaxi Sharma
Nallusamy Sivakumar
author_sort Ameera Al Shehhi
collection DOAJ
description Abstract Rising environmental concerns and fossil fuel depletion necessitate the search for sustainable, alternative energy sources. Biodiesel is emerging as a viable alternative owing to its biodegradability, low toxicity, and reduced greenhouse gas emissions. This review highlights the environmental and economic advantages of biodiesel, with a special emphasis on microbial lipids from wastewater as a promising third-generation feedstock. The novelty of this review is the comprehensive evaluation of wastewater and sewage sludge as low-cost, nutrient-rich substrates for microbial lipid production. In this review, the biodiesel production by direct lipid extraction and microbial conversion routes is discussed. Biodiesel production from different types of industrial wastewaters, such as municipal, dairy, pulp and paper, brewery, and textile wastewater using oleaginous microorganisms is discussed as well. This review revealed that lipid content in different microbes ranged from 27 to 90% when different wastewaters were used as substrates. Further, this review compares the fuel properties of biodiesel derived from plant oils, animal fats, and microbial lipids, their fatty acid profiles, and estimated production costs, and it varies from 0.1 to 0.83 USD/L. In addition, this review also focuses on the biodiesel production from wastewater using microalgae, fungi, and bacteria. Biodiesel with a high cetane number of 64.47 was produced by Cryptococcus curvatus. Finally, key challenges in producing biodiesel from wastewater and future prospects are discussed, emphasizing the potential of wastewater as a substrate for sustainable biodiesel production. Graphical abstract
format Article
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issn 2197-4365
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spelling doaj-art-710d9408c76146479fa4e97f33898cbb2025-08-20T03:03:20ZengSpringerOpenBioresources and Bioprocessing2197-43652025-07-0112112510.1186/s40643-025-00897-2Microbial lipid-based biodiesel production using wastewater: opportunities and challengesAmeera Al Shehhi0Yasmine Souissi1Anu Sadasivan Nair2Zeba Usmani3Minaxi Sharma4Nallusamy Sivakumar5Department of Biology, College of Science, Sultan Qaboos UniversityUniversity of Manouba, ISBST, BVBGR-LR11ES31, Biotechpole Sidi ThabetDepartment of Biology, College of Science, Sultan Qaboos UniversityLaboratory of Lignin Biochemistry, Department of Chemistry and Biotechnology, Tallinn University of TechnologyDepartment of Food Technology, Akal College of Agriculture, Eternal UniversityDepartment of Biology, College of Science, Sultan Qaboos UniversityAbstract Rising environmental concerns and fossil fuel depletion necessitate the search for sustainable, alternative energy sources. Biodiesel is emerging as a viable alternative owing to its biodegradability, low toxicity, and reduced greenhouse gas emissions. This review highlights the environmental and economic advantages of biodiesel, with a special emphasis on microbial lipids from wastewater as a promising third-generation feedstock. The novelty of this review is the comprehensive evaluation of wastewater and sewage sludge as low-cost, nutrient-rich substrates for microbial lipid production. In this review, the biodiesel production by direct lipid extraction and microbial conversion routes is discussed. Biodiesel production from different types of industrial wastewaters, such as municipal, dairy, pulp and paper, brewery, and textile wastewater using oleaginous microorganisms is discussed as well. This review revealed that lipid content in different microbes ranged from 27 to 90% when different wastewaters were used as substrates. Further, this review compares the fuel properties of biodiesel derived from plant oils, animal fats, and microbial lipids, their fatty acid profiles, and estimated production costs, and it varies from 0.1 to 0.83 USD/L. In addition, this review also focuses on the biodiesel production from wastewater using microalgae, fungi, and bacteria. Biodiesel with a high cetane number of 64.47 was produced by Cryptococcus curvatus. Finally, key challenges in producing biodiesel from wastewater and future prospects are discussed, emphasizing the potential of wastewater as a substrate for sustainable biodiesel production. Graphical abstracthttps://doi.org/10.1186/s40643-025-00897-2Microbial lipidsBiodieselWastewaterOleaginous microorganismsLipid compositionBiodiesel properties
spellingShingle Ameera Al Shehhi
Yasmine Souissi
Anu Sadasivan Nair
Zeba Usmani
Minaxi Sharma
Nallusamy Sivakumar
Microbial lipid-based biodiesel production using wastewater: opportunities and challenges
Bioresources and Bioprocessing
Microbial lipids
Biodiesel
Wastewater
Oleaginous microorganisms
Lipid composition
Biodiesel properties
title Microbial lipid-based biodiesel production using wastewater: opportunities and challenges
title_full Microbial lipid-based biodiesel production using wastewater: opportunities and challenges
title_fullStr Microbial lipid-based biodiesel production using wastewater: opportunities and challenges
title_full_unstemmed Microbial lipid-based biodiesel production using wastewater: opportunities and challenges
title_short Microbial lipid-based biodiesel production using wastewater: opportunities and challenges
title_sort microbial lipid based biodiesel production using wastewater opportunities and challenges
topic Microbial lipids
Biodiesel
Wastewater
Oleaginous microorganisms
Lipid composition
Biodiesel properties
url https://doi.org/10.1186/s40643-025-00897-2
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AT anusadasivannair microbiallipidbasedbiodieselproductionusingwastewateropportunitiesandchallenges
AT zebausmani microbiallipidbasedbiodieselproductionusingwastewateropportunitiesandchallenges
AT minaxisharma microbiallipidbasedbiodieselproductionusingwastewateropportunitiesandchallenges
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