A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall
Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemi...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2017/5656340 |
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| author | Tomoko Noguchi Nami Ota Yasushi Mabuchi Shigetaka Yagi Sawako Minami Hisako Okuhira Yuki Yamamoto Yasushi Nakamura Kazuhiko Ino |
| author_facet | Tomoko Noguchi Nami Ota Yasushi Mabuchi Shigetaka Yagi Sawako Minami Hisako Okuhira Yuki Yamamoto Yasushi Nakamura Kazuhiko Ino |
| author_sort | Tomoko Noguchi |
| collection | DOAJ |
| description | Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. A 66-year-old woman presented with postmenopausal bleeding. Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. MRI and PET/CT did not detect any distant or lymph node metastases. She underwent radical hysterectomy, pelvic lymphadenectomy, and total vaginectomy. The pathological diagnosis was FIGO stage IIIA primary cervical MM. She received adjuvant chemotherapy with 6 courses of dacarbazine, but 6 months later, multiple lung metastases were detected. Despite 4 courses of anti-PD-1 antibody (nivolumab) treatment, she died of the disease 13 months after surgery. |
| format | Article |
| id | doaj-art-710d2f1ec18146a0b0c5483dc8ecb2f6 |
| institution | OA Journals |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-710d2f1ec18146a0b0c5483dc8ecb2f62025-08-20T02:06:47ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922017-01-01201710.1155/2017/56563405656340A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal WallTomoko Noguchi0Nami Ota1Yasushi Mabuchi2Shigetaka Yagi3Sawako Minami4Hisako Okuhira5Yuki Yamamoto6Yasushi Nakamura7Kazuhiko Ino8Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, JapanDepartment of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, JapanDepartment of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, JapanDepartment of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, JapanDepartment of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, JapanDepartment of Dermatology, Wakayama Medical University, Wakayama, JapanDepartment of Dermatology, Wakayama Medical University, Wakayama, JapanDivision of Pathology, Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama, JapanDepartment of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, JapanMalignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. A 66-year-old woman presented with postmenopausal bleeding. Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. MRI and PET/CT did not detect any distant or lymph node metastases. She underwent radical hysterectomy, pelvic lymphadenectomy, and total vaginectomy. The pathological diagnosis was FIGO stage IIIA primary cervical MM. She received adjuvant chemotherapy with 6 courses of dacarbazine, but 6 months later, multiple lung metastases were detected. Despite 4 courses of anti-PD-1 antibody (nivolumab) treatment, she died of the disease 13 months after surgery.http://dx.doi.org/10.1155/2017/5656340 |
| spellingShingle | Tomoko Noguchi Nami Ota Yasushi Mabuchi Shigetaka Yagi Sawako Minami Hisako Okuhira Yuki Yamamoto Yasushi Nakamura Kazuhiko Ino A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall Case Reports in Obstetrics and Gynecology |
| title | A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall |
| title_full | A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall |
| title_fullStr | A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall |
| title_full_unstemmed | A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall |
| title_short | A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall |
| title_sort | case of malignant melanoma of the uterine cervix with disseminated metastases throughout the vaginal wall |
| url | http://dx.doi.org/10.1155/2017/5656340 |
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