Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample.
<h4>Purpose</h4>To assess the long-term treatment outcomes of dry eye in patients with and without underlying primary Sjögren's syndrome (SS).<h4>Design</h4>Retrospective longitudinal cohort.<h4>Methods</h4>SS and non-SS dry eye patients with clinic visits fo...
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261241&type=printable |
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| author | David Cui Priya Mathews Gavin Li Shanna VanCourt Esen Akpek |
| author_facet | David Cui Priya Mathews Gavin Li Shanna VanCourt Esen Akpek |
| author_sort | David Cui |
| collection | DOAJ |
| description | <h4>Purpose</h4>To assess the long-term treatment outcomes of dry eye in patients with and without underlying primary Sjögren's syndrome (SS).<h4>Design</h4>Retrospective longitudinal cohort.<h4>Methods</h4>SS and non-SS dry eye patients with clinic visits for a minimum of 5 consecutive years at a tertiary, dedicated dry eye clinic were included. Electronic health records were reviewed to collect data regarding demographics, objective dry eye parameters, treatments utilized at baseline and final visit, and corneal complications observed during follow-up.<h4>Results</h4>Two hundred and two patients (101 SS and 101 randomly selected non-SS), with a mean follow-up of 7.1 years were included. At baseline, mean conjunctival lissamine green staining score was 2.9 and mean corneal fluorescein staining score was 2.0. At last visit, notable improvement in staining score for cornea (-1.1, P < .001) and conjunctiva (-1.8, P < .001) was seen equally in both dry eye groups. Most patients (88.1%) had an escalation of treatment by the final visit, with similar rates in both groups (P = .51). Half (48.9%) of the patients had no conjunctival staining, and a third (34.4%) had no corneal staining at their last visit. Twenty (9.9%) patients experienced a vision-threatening corneal complication, including ulcers and melt, with no difference in occurrences between the groups (P = .64).<h4>Conclusions</h4>The majority of patients in this longitudinal, tertiary clinic-based sample demonstrated improvement in their ocular surface staining score by the final visit with escalation in treatment. Treatments used, improvement achieved, and corneal complication rates leading to loss of vision were similar in both SS and non-SS dry eye groups. |
| format | Article |
| id | doaj-art-710ad4c8424e4241a30d4efe7e0887e3 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-710ad4c8424e4241a30d4efe7e0887e32025-08-20T02:46:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026124110.1371/journal.pone.0261241Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample.David CuiPriya MathewsGavin LiShanna VanCourtEsen Akpek<h4>Purpose</h4>To assess the long-term treatment outcomes of dry eye in patients with and without underlying primary Sjögren's syndrome (SS).<h4>Design</h4>Retrospective longitudinal cohort.<h4>Methods</h4>SS and non-SS dry eye patients with clinic visits for a minimum of 5 consecutive years at a tertiary, dedicated dry eye clinic were included. Electronic health records were reviewed to collect data regarding demographics, objective dry eye parameters, treatments utilized at baseline and final visit, and corneal complications observed during follow-up.<h4>Results</h4>Two hundred and two patients (101 SS and 101 randomly selected non-SS), with a mean follow-up of 7.1 years were included. At baseline, mean conjunctival lissamine green staining score was 2.9 and mean corneal fluorescein staining score was 2.0. At last visit, notable improvement in staining score for cornea (-1.1, P < .001) and conjunctiva (-1.8, P < .001) was seen equally in both dry eye groups. Most patients (88.1%) had an escalation of treatment by the final visit, with similar rates in both groups (P = .51). Half (48.9%) of the patients had no conjunctival staining, and a third (34.4%) had no corneal staining at their last visit. Twenty (9.9%) patients experienced a vision-threatening corneal complication, including ulcers and melt, with no difference in occurrences between the groups (P = .64).<h4>Conclusions</h4>The majority of patients in this longitudinal, tertiary clinic-based sample demonstrated improvement in their ocular surface staining score by the final visit with escalation in treatment. Treatments used, improvement achieved, and corneal complication rates leading to loss of vision were similar in both SS and non-SS dry eye groups.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261241&type=printable |
| spellingShingle | David Cui Priya Mathews Gavin Li Shanna VanCourt Esen Akpek Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample. PLoS ONE |
| title | Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample. |
| title_full | Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample. |
| title_fullStr | Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample. |
| title_full_unstemmed | Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample. |
| title_short | Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample. |
| title_sort | outcomes of sjogren s versus non sjogren s related dry eye in a longitudinal tertiary clinic based sample |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261241&type=printable |
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