PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells

PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells

Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide (NO) synthase. Guanosine 5′-triphosphate cyclohydrolase-I (GTPCH-I) is a key limiting enzyme for BH4 synthesis. In the present in vitro study, we investigated whether peroxisome proliferator-activated receptor α (PPAR-α)...

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Main Authors: Jinbo Liu, Changlin Lu, Fuwang Li, Haining Wang, Liyun He, Yanting Hao, Alex F. Chen, Huijie An, Xian Wang, Tianpei Hong, Guang Wang
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2011/523520
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http://dx.doi.org/10.1155/2011/523520

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