Redox Balance in Cancer in the Context of Tumor Prevention and Treatment
Malignant neoplasms constitute a substantial health concern for the human population, currently ranking as the second leading cause of mortality worldwide. In 2022, approximately 10 million deaths were attributable to cancer, and projections estimate that this number will rise to 35 million in 2050....
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| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/5/1149 |
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| author | Paweł Sutkowy Przemysław Czeleń |
| author_facet | Paweł Sutkowy Przemysław Czeleń |
| author_sort | Paweł Sutkowy |
| collection | DOAJ |
| description | Malignant neoplasms constitute a substantial health concern for the human population, currently ranking as the second leading cause of mortality worldwide. In 2022, approximately 10 million deaths were attributable to cancer, and projections estimate that this number will rise to 35 million in 2050. Consequently, the development of effective cancer treatments and prevention strategies remains a primary focus of medical research. In this context, the impacts on the redox balance are being considered. The objective of this study was to present the current knowledge on oxidation and reduction processes in cancer. This review discloses the intricate and multifaceted interplay of oxidoreductive systems during carcinogenesis, which engenders discordant findings in the domain of tumor prevention and treatment. This study also examines the controversies surrounding the use of antioxidants, including their impact on other therapeutic interventions. The review offers a comprehensive overview of the existing knowledge on the subject, concluding that personalized and precise anticancer therapies targeting the redox processes can serve as both effective diagnostic and therapeutic tools. |
| format | Article |
| id | doaj-art-710396f140c647cb94a1f10e1e20ffb3 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-710396f140c647cb94a1f10e1e20ffb32025-08-20T03:14:42ZengMDPI AGBiomedicines2227-90592025-05-01135114910.3390/biomedicines13051149Redox Balance in Cancer in the Context of Tumor Prevention and TreatmentPaweł Sutkowy0Przemysław Czeleń1Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24, 85-092 Bydgoszcz, PolandDepartment of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpinskiego 5, 85-096 Bydgoszcz, PolandMalignant neoplasms constitute a substantial health concern for the human population, currently ranking as the second leading cause of mortality worldwide. In 2022, approximately 10 million deaths were attributable to cancer, and projections estimate that this number will rise to 35 million in 2050. Consequently, the development of effective cancer treatments and prevention strategies remains a primary focus of medical research. In this context, the impacts on the redox balance are being considered. The objective of this study was to present the current knowledge on oxidation and reduction processes in cancer. This review discloses the intricate and multifaceted interplay of oxidoreductive systems during carcinogenesis, which engenders discordant findings in the domain of tumor prevention and treatment. This study also examines the controversies surrounding the use of antioxidants, including their impact on other therapeutic interventions. The review offers a comprehensive overview of the existing knowledge on the subject, concluding that personalized and precise anticancer therapies targeting the redox processes can serve as both effective diagnostic and therapeutic tools.https://www.mdpi.com/2227-9059/13/5/1149oxidantsantioxidantscancerpreventiondiagnosistreatment |
| spellingShingle | Paweł Sutkowy Przemysław Czeleń Redox Balance in Cancer in the Context of Tumor Prevention and Treatment Biomedicines oxidants antioxidants cancer prevention diagnosis treatment |
| title | Redox Balance in Cancer in the Context of Tumor Prevention and Treatment |
| title_full | Redox Balance in Cancer in the Context of Tumor Prevention and Treatment |
| title_fullStr | Redox Balance in Cancer in the Context of Tumor Prevention and Treatment |
| title_full_unstemmed | Redox Balance in Cancer in the Context of Tumor Prevention and Treatment |
| title_short | Redox Balance in Cancer in the Context of Tumor Prevention and Treatment |
| title_sort | redox balance in cancer in the context of tumor prevention and treatment |
| topic | oxidants antioxidants cancer prevention diagnosis treatment |
| url | https://www.mdpi.com/2227-9059/13/5/1149 |
| work_keys_str_mv | AT pawełsutkowy redoxbalanceincancerinthecontextoftumorpreventionandtreatment AT przemysławczelen redoxbalanceincancerinthecontextoftumorpreventionandtreatment |