Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lobe epilepsy

Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lobe epilepsy

Efficient treatment of temporal lobe epilepsy (TLE) remains challenging due to limited understanding of cellular and network changes and the interference of novel antiepileptic drugs (AEDs) with tissue reorganisation. This study compared the effects of brivaracetam and levetiracetam on histological...

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Main Authors: Krisztina Kelemen, Máté Sárosi, Ágnes Csüdör, Károly Orbán-Kis, Hanga Kelemen, László Bába, Zsolt Gáll, Eszter Horváth, István Katona, Tibor Szilágyi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
temporal lobe epilepsy (TLE)
antiepileptic drugs
microglia-activation
brain-regions
epileptic circuitry
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1553545/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1553545/full

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