Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study
Background: Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. Probiotics, including Lactobacillus acidophilus, Enterococcus faecium, and Saccharomyces cerevisiae, have shown promise in maintaining a he...
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| Format: | Article |
| Language: | English |
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Tripoli University
2025-01-01
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| Series: | Open Veterinary Journal |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=224880 |
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| author | Francesca Perondi Ilaria Lippi Natascia Bruni Nicolò Lonigro Elisa Martello |
| author_facet | Francesca Perondi Ilaria Lippi Natascia Bruni Nicolò Lonigro Elisa Martello |
| author_sort | Francesca Perondi |
| collection | DOAJ |
| description | Background:
Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. Probiotics, including Lactobacillus acidophilus, Enterococcus faecium, and Saccharomyces cerevisiae, have shown promise in maintaining a healthy gut microbiota in both healthy and CKD animals.
Aim:
This pilot double-blinded, randomized controlled study aimed to assess the effects of a feed supplement containing these probiotics on clinical parameters and fecal consistency in dogs with chronic kidney disease (CKD) and pronounce intestinal disorders.
Methods:
Eight dogs with CKD were randomly assigned to receive the supplement (TRT, n=4) or placebo (CTR, n=4) alongside a renal commercial complete dietetic feed and another supplement specific for CKD for 50 days. Clinical parameters, such as body condition score (BCS) and fecal score (FS), were regularly monitored.
Results:
The dogs in the TRT group exhibited improvements in fecal consistency and clinical parameters compared with the CTR group.
Conclusion:
The feed supplement under investigation appears beneficial for improving clinical condition, gut health, and stool quality in dogs with CKD. Future studies with larger sample sizes and microbiota analyses are needed to gain a better understanding of the potential benefits of this supplement in managing CKD in dogs. [Open Vet J 2025; 15(1.000): 307-313] |
| format | Article |
| id | doaj-art-70fb69556479460aa02bf6408e2fe276 |
| institution | DOAJ |
| issn | 2226-4485 2218-6050 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj-art-70fb69556479460aa02bf6408e2fe2762025-08-20T03:06:53ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502025-01-0115130731310.5455/OVJ.2025.v15.i1.29224880Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot studyFrancesca Perondi0Ilaria Lippi1Natascia Bruni2Nicolò Lonigro3Elisa Martello4Department of Veterinary Science, University of Pisa, 56122 San Piero a Grado (Pisa), Italy Department of Veterinary Science, University of Pisa, 56122 San Piero a Grado (Pisa), Italy Candioli Pharma srl Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy Division of Epidemiology and Public Health, School of Medicine, University of Not-tingham, UKBackground: Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. Probiotics, including Lactobacillus acidophilus, Enterococcus faecium, and Saccharomyces cerevisiae, have shown promise in maintaining a healthy gut microbiota in both healthy and CKD animals. Aim: This pilot double-blinded, randomized controlled study aimed to assess the effects of a feed supplement containing these probiotics on clinical parameters and fecal consistency in dogs with chronic kidney disease (CKD) and pronounce intestinal disorders. Methods: Eight dogs with CKD were randomly assigned to receive the supplement (TRT, n=4) or placebo (CTR, n=4) alongside a renal commercial complete dietetic feed and another supplement specific for CKD for 50 days. Clinical parameters, such as body condition score (BCS) and fecal score (FS), were regularly monitored. Results: The dogs in the TRT group exhibited improvements in fecal consistency and clinical parameters compared with the CTR group. Conclusion: The feed supplement under investigation appears beneficial for improving clinical condition, gut health, and stool quality in dogs with CKD. Future studies with larger sample sizes and microbiota analyses are needed to gain a better understanding of the potential benefits of this supplement in managing CKD in dogs. [Open Vet J 2025; 15(1.000): 307-313]http://www.ejmanager.com/fulltextpdf.php?mno=224880renal diseasebeneficial bacteriagutstool texturecanineckd |
| spellingShingle | Francesca Perondi Ilaria Lippi Natascia Bruni Nicolò Lonigro Elisa Martello Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study Open Veterinary Journal renal disease beneficial bacteria gut stool texture canine ckd |
| title | Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study |
| title_full | Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study |
| title_fullStr | Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study |
| title_full_unstemmed | Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study |
| title_short | Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study |
| title_sort | effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders a pilot study |
| topic | renal disease beneficial bacteria gut stool texture canine ckd |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=224880 |
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