Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors

Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors

Epithelial Cell Transformation Factor 2 (ECT2) is highly expressed in a variety of cancers, including gynecological tumors. The mislocalization of ECT2 can abnormally activate Ras homolog family member A (RhoA) in the Ras homolog gene family (Rho) Guanine nucleotide Exchange Factor (GEF) family. Act...

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Bibliographic Details
Main Authors:	Liying Sheng, Meili Liang, Yueli Wang, Zhimei Zhou, Yajing Xie, Yumin Ke, Zhuna Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	Ect2 RhoA ROCK ovarian cancer cervical cancer endometrial cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1602649/full
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