Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors
Epithelial Cell Transformation Factor 2 (ECT2) is highly expressed in a variety of cancers, including gynecological tumors. The mislocalization of ECT2 can abnormally activate Ras homolog family member A (RhoA) in the Ras homolog gene family (Rho) Guanine nucleotide Exchange Factor (GEF) family. Act...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1602649/full |
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| author | Liying Sheng Meili Liang Yueli Wang Zhimei Zhou Yajing Xie Yumin Ke Zhuna Wu |
| author_facet | Liying Sheng Meili Liang Yueli Wang Zhimei Zhou Yajing Xie Yumin Ke Zhuna Wu |
| author_sort | Liying Sheng |
| collection | DOAJ |
| description | Epithelial Cell Transformation Factor 2 (ECT2) is highly expressed in a variety of cancers, including gynecological tumors. The mislocalization of ECT2 can abnormally activate Ras homolog family member A (RhoA) in the Ras homolog gene family (Rho) Guanine nucleotide Exchange Factor (GEF) family. Activated RhoA binds to Rho-associated protein kinase (ROCK), phosphorylates various target proteins, triggers a cascade reaction, regulates the functions of downstream proteins, and thereby plays an important role in the occurrence and development of tumors. This article reviews the roles of ECT2 and RhoA/ROCK signaling pathways in ovarian cancer, cervical cancer, and endometrial cancer, and summarizes and discusses the research progress of downstream molecules, transduction pathways, and mechanisms related to them. Through comprehensive analysis and summary of the current research results, it is revealed that the ECT2/RhoA/ROCK signaling pathway and related crosstalk pathways play an important role in the occurrence, development, and metastasis of gynecological tumors. This article aims to provide a basis for related research and offer relevant references for the treatment of gynecological tumors in the future. |
| format | Article |
| id | doaj-art-70f3b3db8af94c3da520fd070ddde61e |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-70f3b3db8af94c3da520fd070ddde61e2025-08-20T03:31:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.16026491602649Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumorsLiying ShengMeili LiangYueli WangZhimei ZhouYajing XieYumin KeZhuna WuEpithelial Cell Transformation Factor 2 (ECT2) is highly expressed in a variety of cancers, including gynecological tumors. The mislocalization of ECT2 can abnormally activate Ras homolog family member A (RhoA) in the Ras homolog gene family (Rho) Guanine nucleotide Exchange Factor (GEF) family. Activated RhoA binds to Rho-associated protein kinase (ROCK), phosphorylates various target proteins, triggers a cascade reaction, regulates the functions of downstream proteins, and thereby plays an important role in the occurrence and development of tumors. This article reviews the roles of ECT2 and RhoA/ROCK signaling pathways in ovarian cancer, cervical cancer, and endometrial cancer, and summarizes and discusses the research progress of downstream molecules, transduction pathways, and mechanisms related to them. Through comprehensive analysis and summary of the current research results, it is revealed that the ECT2/RhoA/ROCK signaling pathway and related crosstalk pathways play an important role in the occurrence, development, and metastasis of gynecological tumors. This article aims to provide a basis for related research and offer relevant references for the treatment of gynecological tumors in the future.https://www.frontiersin.org/articles/10.3389/fcell.2025.1602649/fullEct2RhoAROCKovarian cancercervical cancerendometrial cancer |
| spellingShingle | Liying Sheng Meili Liang Yueli Wang Zhimei Zhou Yajing Xie Yumin Ke Zhuna Wu Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors Frontiers in Cell and Developmental Biology Ect2 RhoA ROCK ovarian cancer cervical cancer endometrial cancer |
| title | Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors |
| title_full | Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors |
| title_fullStr | Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors |
| title_full_unstemmed | Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors |
| title_short | Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors |
| title_sort | research progress of ect2 and rhoa related signaling pathways in gynecological tumors |
| topic | Ect2 RhoA ROCK ovarian cancer cervical cancer endometrial cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1602649/full |
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