Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort
Purpose Our aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-...
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| Language: | English |
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BMJ Publishing Group
2021-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/6/e046928.full |
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| author | Alex Brown David Roder Newell Johnson Gail Garvey Karen Canfell Lisa M Jamieson Joanne Hedges Cathy Leane Megan Smith Isaac Hill Xiangqun Ju Sneha Sethi Richard M Logan Annika Antonsson |
| author_facet | Alex Brown David Roder Newell Johnson Gail Garvey Karen Canfell Lisa M Jamieson Joanne Hedges Cathy Leane Megan Smith Isaac Hill Xiangqun Ju Sneha Sethi Richard M Logan Annika Antonsson |
| author_sort | Alex Brown |
| collection | DOAJ |
| description | Purpose Our aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians.Participants Participants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted.Findings to date Of the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up).Future plans Further funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken. |
| format | Article |
| id | doaj-art-70f397b456fb4e02a4f16dc2cb5f7a6b |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-70f397b456fb4e02a4f16dc2cb5f7a6b2025-08-20T02:17:57ZengBMJ Publishing GroupBMJ Open2044-60552021-06-0111610.1136/bmjopen-2020-046928Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohortAlex Brown0David Roder1Newell Johnson2Gail Garvey3Karen Canfell4Lisa M Jamieson5Joanne Hedges6Cathy Leane7Megan Smith8Isaac Hill9Xiangqun Ju10Sneha Sethi11Richard M Logan12Annika Antonsson13Indigenous Genomics, Australian National University, Canberra, ACT, Australia2 Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia9 Griffith University - Gold Coast Campus, Southport, Queensland, AustraliaSchool of Public Health, Faculty of Medicine, The University of Queensland, Herston, Queensland, AustraliaThe Daffodil Centre, The University of Sydney, a Joint Venture with Cancer Council NSW, Sydney, New South Wales, Australia1 Australian Research Centre for Population Oral Health, The University of Adelaide, Adelaide, South Australia, Australia3 Univ Adelaide, Adelaide, South Australia, AustraliaWomen’s and Children’s Health Network, SA Health, Adelaide, South Australia, Australia10 Cancer Council New South Wales, Woolloomooloo, New South Wales, Australia5 Aboriginal Health Council of South Australia, Adelaide, South Australia, Australia7 Adelaide Dental School, University of Adelaide, Adelaide, South Australia, Australia1 Australian Research Centre for Population Oral Health, The University of Adelaide, Adelaide, South Australia, Australia3 Univ Adelaide, Adelaide, South Australia, Australia11 Queensland Univ Technol, Brisbane, Queensland, AustraliaPurpose Our aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians.Participants Participants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted.Findings to date Of the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up).Future plans Further funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken.https://bmjopen.bmj.com/content/11/6/e046928.full |
| spellingShingle | Alex Brown David Roder Newell Johnson Gail Garvey Karen Canfell Lisa M Jamieson Joanne Hedges Cathy Leane Megan Smith Isaac Hill Xiangqun Ju Sneha Sethi Richard M Logan Annika Antonsson Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort BMJ Open |
| title | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort |
| title_full | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort |
| title_fullStr | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort |
| title_full_unstemmed | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort |
| title_short | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort |
| title_sort | cohort profile indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study a prospective longitudinal cohort |
| url | https://bmjopen.bmj.com/content/11/6/e046928.full |
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