Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study
Context: Central nervous system germ cell tumors (CNSGCTs) though rare is the second most common extragonadal site for GCTs. Aims: To determine the clinicopathological features of CNSGCTs diagnosed at our center. Settings and Design: A retrospective study of all histologically diagnosed CNSGCTs, dur...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_959_22 |
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| author | Sreelekha Appasani Neelima Radhakrishnan Anitha Mathews |
| author_facet | Sreelekha Appasani Neelima Radhakrishnan Anitha Mathews |
| author_sort | Sreelekha Appasani |
| collection | DOAJ |
| description | Context:
Central nervous system germ cell tumors (CNSGCTs) though rare is the second most common extragonadal site for GCTs.
Aims:
To determine the clinicopathological features of CNSGCTs diagnosed at our center.
Settings and Design:
A retrospective study of all histologically diagnosed CNSGCTs, during 2006-2019.
Materials and Methods:
The patients’ data were retrieved from the hospital information systems and analyzed.
Statistical Analysis:
Data on categorical variables were analyzed as percentages, and data on continuous variables calculated as mean. Chi-square test or Fisher’s exact test was used to study association between variables.
Results:
Of the total 34 cases with CNSGCT, age ranged from 1 to 27 years, majority in the second decade (19/34; 56%). Male: female (M: F) ratio was 1.6:1. Single site involvement was seen in 27 cases (27/34; 79%), whereas seven (7/34; 21%) showed bi/multifocal involvement. Among the unifocal cases, common sites involved were suprasellar (12/27; 44.4%), closely followed by the pineal (10/27; 37%). All multifocal tumors affected suprasellar compartment, being bifocal with pineal in four cases. A male gender predilection was noted among pineal region (9/10;90%) and multifocal tumors (5/7;71%). Germinoma was the commonest subtype (21/34; 61.8%) with male gender predilection (17/21; 81%) (M: F =4.3:1), with female predilection seen among mixed GCTs (MGCTs) (8/10; 80%) (M: F =1:4) and suprasellar location (M: F =1:2). Serum tumor markers (25 cases) and CSF markers (7 cases) were concordant with histology in all, except two cases.
Conclusion:
Though histology and immunohistochemistry were diagnostic, correlation between serum and/or CSF marker was essential to rule out GCT component(s) that may be missed on biopsy due to sampling error. |
| format | Article |
| id | doaj-art-70f1927e16db43fa8e294adbceb6c2ac |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-70f1927e16db43fa8e294adbceb6c2ac2025-02-07T13:56:32ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167231231710.4103/ijpm.ijpm_959_22Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective studySreelekha AppasaniNeelima RadhakrishnanAnitha MathewsContext: Central nervous system germ cell tumors (CNSGCTs) though rare is the second most common extragonadal site for GCTs. Aims: To determine the clinicopathological features of CNSGCTs diagnosed at our center. Settings and Design: A retrospective study of all histologically diagnosed CNSGCTs, during 2006-2019. Materials and Methods: The patients’ data were retrieved from the hospital information systems and analyzed. Statistical Analysis: Data on categorical variables were analyzed as percentages, and data on continuous variables calculated as mean. Chi-square test or Fisher’s exact test was used to study association between variables. Results: Of the total 34 cases with CNSGCT, age ranged from 1 to 27 years, majority in the second decade (19/34; 56%). Male: female (M: F) ratio was 1.6:1. Single site involvement was seen in 27 cases (27/34; 79%), whereas seven (7/34; 21%) showed bi/multifocal involvement. Among the unifocal cases, common sites involved were suprasellar (12/27; 44.4%), closely followed by the pineal (10/27; 37%). All multifocal tumors affected suprasellar compartment, being bifocal with pineal in four cases. A male gender predilection was noted among pineal region (9/10;90%) and multifocal tumors (5/7;71%). Germinoma was the commonest subtype (21/34; 61.8%) with male gender predilection (17/21; 81%) (M: F =4.3:1), with female predilection seen among mixed GCTs (MGCTs) (8/10; 80%) (M: F =1:4) and suprasellar location (M: F =1:2). Serum tumor markers (25 cases) and CSF markers (7 cases) were concordant with histology in all, except two cases. Conclusion: Though histology and immunohistochemistry were diagnostic, correlation between serum and/or CSF marker was essential to rule out GCT component(s) that may be missed on biopsy due to sampling error.https://journals.lww.com/10.4103/ijpm.ijpm_959_22bi/multifocalcentral nervous systemgerm cell tumorsgerminomamixed germ cell tumorpinealsuprasellar |
| spellingShingle | Sreelekha Appasani Neelima Radhakrishnan Anitha Mathews Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study Indian Journal of Pathology and Microbiology bi/multifocal central nervous system germ cell tumors germinoma mixed germ cell tumor pineal suprasellar |
| title | Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study |
| title_full | Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study |
| title_fullStr | Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study |
| title_full_unstemmed | Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study |
| title_short | Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study |
| title_sort | clinicopathological spectrum of central nervous system germ cell tumors a single institution retrospective study |
| topic | bi/multifocal central nervous system germ cell tumors germinoma mixed germ cell tumor pineal suprasellar |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_959_22 |
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