Oxidative Stress and Its Biomarkers in Cardiovascular Diseases
Abstract Background Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body Surplus levels of reactive oxygen species induce damage to cellular macromolecules such a...
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| Format: | Article |
| Language: | English |
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BMC
2024-10-01
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| Series: | Artery Research |
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| Online Access: | https://doi.org/10.1007/s44200-024-00062-8 |
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| author | Julija Valaitienė Agnė Laučytė-Cibulskienė |
| author_facet | Julija Valaitienė Agnė Laučytė-Cibulskienė |
| author_sort | Julija Valaitienė |
| collection | DOAJ |
| description | Abstract Background Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availability, vasoconstriction, and the development of procoagulant and proinflammatory states in blood vessels. Conclusion Improved knowledge of biomolecular processes triggered by oxidative stress has helped develop tools for assessing oxidative stress markers and applying them in clinical settings. Nevertheless, some research gaps should be filled, specifically by defining the most clinically relevant biomarkers for oxidative stress with high sensitivity and specificity for CVD. |
| format | Article |
| id | doaj-art-70f0769e6b3846f2bc241ef6924e35c4 |
| institution | Kabale University |
| issn | 1876-4401 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj-art-70f0769e6b3846f2bc241ef6924e35c42025-02-02T12:14:52ZengBMCArtery Research1876-44012024-10-0130111210.1007/s44200-024-00062-8Oxidative Stress and Its Biomarkers in Cardiovascular DiseasesJulija Valaitienė0Agnė Laučytė-Cibulskienė1Faculty of Medicine, Vilnius UniversityDepartment of Nephrology, Skåne University HospitalAbstract Background Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availability, vasoconstriction, and the development of procoagulant and proinflammatory states in blood vessels. Conclusion Improved knowledge of biomolecular processes triggered by oxidative stress has helped develop tools for assessing oxidative stress markers and applying them in clinical settings. Nevertheless, some research gaps should be filled, specifically by defining the most clinically relevant biomarkers for oxidative stress with high sensitivity and specificity for CVD.https://doi.org/10.1007/s44200-024-00062-8BiomarkersCardiovascular diseasesEndothelial cell dysfunctionInflammationOxidative stressReactive oxygen species |
| spellingShingle | Julija Valaitienė Agnė Laučytė-Cibulskienė Oxidative Stress and Its Biomarkers in Cardiovascular Diseases Artery Research Biomarkers Cardiovascular diseases Endothelial cell dysfunction Inflammation Oxidative stress Reactive oxygen species |
| title | Oxidative Stress and Its Biomarkers in Cardiovascular Diseases |
| title_full | Oxidative Stress and Its Biomarkers in Cardiovascular Diseases |
| title_fullStr | Oxidative Stress and Its Biomarkers in Cardiovascular Diseases |
| title_full_unstemmed | Oxidative Stress and Its Biomarkers in Cardiovascular Diseases |
| title_short | Oxidative Stress and Its Biomarkers in Cardiovascular Diseases |
| title_sort | oxidative stress and its biomarkers in cardiovascular diseases |
| topic | Biomarkers Cardiovascular diseases Endothelial cell dysfunction Inflammation Oxidative stress Reactive oxygen species |
| url | https://doi.org/10.1007/s44200-024-00062-8 |
| work_keys_str_mv | AT julijavalaitiene oxidativestressanditsbiomarkersincardiovasculardiseases AT agnelaucytecibulskiene oxidativestressanditsbiomarkersincardiovasculardiseases |