Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer
Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally, insulin is associated with metabolism, wherea...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2017-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=198;epage=206;aulast=Amutha |
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| _version_ | 1849724857545129984 |
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| author | Periyasamy Amutha Thangarajan Rajkumar |
| author_facet | Periyasamy Amutha Thangarajan Rajkumar |
| author_sort | Periyasamy Amutha |
| collection | DOAJ |
| description | Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally, insulin is associated with metabolism, whereas Insulin like growth factors (IGFs) are involved in cell proliferation. Hence, Insulin-like growth factor binding proteins (IGFBPs) determines the bioavailability of IGFs in circulation. The interplay between these molecules such as insulin, IGFs, IGFBPs and insulin-like growth factor receptor 1 (IGF1R) may be crucial for ovarian cancer cell biology and cancer progression. However, the IGF1R inhibitors exhibiting potent activity on IGF/IGF1R also demonstrated activity against OC cells. The combination therapy of drugs may prove to be beneficial in clinical management of OC. This review describes both molecular and clinical associations between insulin and IGF1 signaling pathways in ovarian cancer. The data was collected using PubMed search engine with the following key words such as ovarian cancer, IGFs, IGFBP, IGF1Rs and ovarian cancer. |
| format | Article |
| id | doaj-art-70edbbe5ea174567a1e6a32ab30a0efb |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-70edbbe5ea174567a1e6a32ab30a0efb2025-08-20T03:10:38ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512017-01-0138219820610.4103/ijmpo.ijmpo_3_17Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancerPeriyasamy AmuthaThangarajan RajkumarInsulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally, insulin is associated with metabolism, whereas Insulin like growth factors (IGFs) are involved in cell proliferation. Hence, Insulin-like growth factor binding proteins (IGFBPs) determines the bioavailability of IGFs in circulation. The interplay between these molecules such as insulin, IGFs, IGFBPs and insulin-like growth factor receptor 1 (IGF1R) may be crucial for ovarian cancer cell biology and cancer progression. However, the IGF1R inhibitors exhibiting potent activity on IGF/IGF1R also demonstrated activity against OC cells. The combination therapy of drugs may prove to be beneficial in clinical management of OC. This review describes both molecular and clinical associations between insulin and IGF1 signaling pathways in ovarian cancer. The data was collected using PubMed search engine with the following key words such as ovarian cancer, IGFs, IGFBP, IGF1Rs and ovarian cancer.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=198;epage=206;aulast=AmuthaInsulin-like growth factorinsulin-like growth factor-binding proteinsinsulin-like growth factor receptorobesityovarian cancerprognostic value |
| spellingShingle | Periyasamy Amutha Thangarajan Rajkumar Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer Indian Journal of Medical and Paediatric Oncology Insulin-like growth factor insulin-like growth factor-binding proteins insulin-like growth factor receptor obesity ovarian cancer prognostic value |
| title | Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer |
| title_full | Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer |
| title_fullStr | Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer |
| title_full_unstemmed | Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer |
| title_short | Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer |
| title_sort | role of insulin like growth factor insulin like growth factor receptors and insulin like growth factor binding proteins in ovarian cancer |
| topic | Insulin-like growth factor insulin-like growth factor-binding proteins insulin-like growth factor receptor obesity ovarian cancer prognostic value |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=198;epage=206;aulast=Amutha |
| work_keys_str_mv | AT periyasamyamutha roleofinsulinlikegrowthfactorinsulinlikegrowthfactorreceptorsandinsulinlikegrowthfactorbindingproteinsinovariancancer AT thangarajanrajkumar roleofinsulinlikegrowthfactorinsulinlikegrowthfactorreceptorsandinsulinlikegrowthfactorbindingproteinsinovariancancer |