Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018
BackgroundUtilizing data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the association between Relative Fat Mass (RFM) and lumbar spine bone mineral density (BMD) in adults, specifically evaluating the impact of RFM on lumbar BMD and determining the cons...
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Frontiers Media S.A.
2025-07-01
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| author | Xing-An Jiang Xing-An Jiang Hong-Li Zhang Bin-Tao Ye Shao-Qi Fang Jia-Jin Zhang Hao-Lin Yu Jun-Bo Liang Jun-Bo Liang |
| author_facet | Xing-An Jiang Xing-An Jiang Hong-Li Zhang Bin-Tao Ye Shao-Qi Fang Jia-Jin Zhang Hao-Lin Yu Jun-Bo Liang Jun-Bo Liang |
| author_sort | Xing-An Jiang |
| collection | DOAJ |
| description | BackgroundUtilizing data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the association between Relative Fat Mass (RFM) and lumbar spine bone mineral density (BMD) in adults, specifically evaluating the impact of RFM on lumbar BMD and determining the consistency of this relationship across diverse populations.MethodsCross-sectional data from 9,238 adults aged ≥20 years in the 2011–2018 NHANES cycles were analyzed. Relative fat mass (RFM) values were derived through a formula incorporating waist circumference (WC) and height. The relationship between RFM and lumbar BMD was assessed through weighted multiple linear regression models, subgroup analyses, and smooth curve fitting.ResultsAfter adjusting for multiple covariates, RFM exhibited a statistically significant inverse relationship with lumbar spine BMD. In the fully adjusted model, a per-unit increment in RFM was linked to a decline of 0.0110 g/cm2 in lumbar BMD (β = −0.0110, 95% CI: −0.0132 to-0.0088; p < 0.0001). Additionally, an inflection point was detected at RFM = 20.5847 (p < 0.001), with significantly distinct correlations between RFM and lumbar spine BMD when values were above or below this point. Subgroup analyses confirmed the persistence of this inverse relationship in virtually all population subgroups stratified by demographic characteristics or health statuses.ConclusionThe analysis reveals a notable inverse relationship between RFM values and BMD measurements in the lumbar spine, suggesting that elevated RFM levels might correlate with reduced BMD and heightened susceptibility to osteoporosis (OP) development. These observations highlight the critical role of evaluating adipose distribution patterns when devising preventive measures against OP and support employing RFM as an potential indicator for initiating early clinical interventions aimed at mitigating bone density deterioration. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-70e8bbe801fb4f879ac94b3ab2bda31d2025-08-20T03:28:53ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-07-011310.3389/fpubh.2025.15842931584293Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018Xing-An Jiang0Xing-An Jiang1Hong-Li Zhang2Bin-Tao Ye3Shao-Qi Fang4Jia-Jin Zhang5Hao-Lin Yu6Jun-Bo Liang7Jun-Bo Liang8Department of Orthopedic, Taizhou Hospital Affiliated to Zhejiang University School of Medicine, Taizhou, ChinaSchool of Medicine, Zhejiang University, Hangzhou, ChinaOrthopedic Department, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, ChinaOrthopedic Department, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, ChinaSchool of Medicine, Shaoxing University, Shaoxing, ChinaOrthopedic Department, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, ChinaOrthopedic Department, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, ChinaDepartment of Orthopedic, Taizhou Hospital Affiliated to Zhejiang University School of Medicine, Taizhou, ChinaSchool of Medicine, Zhejiang University, Hangzhou, ChinaBackgroundUtilizing data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the association between Relative Fat Mass (RFM) and lumbar spine bone mineral density (BMD) in adults, specifically evaluating the impact of RFM on lumbar BMD and determining the consistency of this relationship across diverse populations.MethodsCross-sectional data from 9,238 adults aged ≥20 years in the 2011–2018 NHANES cycles were analyzed. Relative fat mass (RFM) values were derived through a formula incorporating waist circumference (WC) and height. The relationship between RFM and lumbar BMD was assessed through weighted multiple linear regression models, subgroup analyses, and smooth curve fitting.ResultsAfter adjusting for multiple covariates, RFM exhibited a statistically significant inverse relationship with lumbar spine BMD. In the fully adjusted model, a per-unit increment in RFM was linked to a decline of 0.0110 g/cm2 in lumbar BMD (β = −0.0110, 95% CI: −0.0132 to-0.0088; p < 0.0001). Additionally, an inflection point was detected at RFM = 20.5847 (p < 0.001), with significantly distinct correlations between RFM and lumbar spine BMD when values were above or below this point. Subgroup analyses confirmed the persistence of this inverse relationship in virtually all population subgroups stratified by demographic characteristics or health statuses.ConclusionThe analysis reveals a notable inverse relationship between RFM values and BMD measurements in the lumbar spine, suggesting that elevated RFM levels might correlate with reduced BMD and heightened susceptibility to osteoporosis (OP) development. These observations highlight the critical role of evaluating adipose distribution patterns when devising preventive measures against OP and support employing RFM as an potential indicator for initiating early clinical interventions aimed at mitigating bone density deterioration.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1584293/fullrelative fat massbone mineral densityosteoporosisNHANESobesity |
| spellingShingle | Xing-An Jiang Xing-An Jiang Hong-Li Zhang Bin-Tao Ye Shao-Qi Fang Jia-Jin Zhang Hao-Lin Yu Jun-Bo Liang Jun-Bo Liang Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 Frontiers in Public Health relative fat mass bone mineral density osteoporosis NHANES obesity |
| title | Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 |
| title_full | Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 |
| title_fullStr | Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 |
| title_full_unstemmed | Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 |
| title_short | Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 |
| title_sort | negative correlation between relative fat mass and bone mineral density nhanes 2011 2018 |
| topic | relative fat mass bone mineral density osteoporosis NHANES obesity |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1584293/full |
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