Identification of potent inhibitors of Leishmania donovani and Leishmania infantum chagasi, the causative agents of Old and New World visceral leishmaniasis

Abstract The drug discovery pipeline for neglected kinetoplastid diseases remains sparse. In particular, the field of leishmaniasis drug discovery has had limited success in translating potential drug candidates into viable therapies. Here, we describe the development of two lead compounds, BZ-1 and...

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Main Authors: Bilal Zulfiqar, Fabio Antonio Colombo, Juliana Barbosa Nunes, Patricia Ferreira Espuri, Aurea Favero Ferreira, Sujatha Manthri, Manu De Rycker, Marcos Jose Marques, Vicky M. Avery
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08386-0
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