Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day
The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality in invasive forms of the disease, but also with severe consequences in survivors, who are not recorded in our country.The aim of study: to analyze clinical ma...
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Journal Infectology
2024-01-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1562 |
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| author | A. A. Vilnits Yu. V. Lobzin N. V. Skripchenko L. N. Mazankova O. I. Klimova A. Yu. Rtishchev I. M. Osmanov K. V. Markova N. H. Tkhakushinova G. P. Martinova A. U. Sabitov R. K. Babik I. Ya. Izvekova V. V. Krasnov E. V. Sidorenkova O. V. Borisova N. M. Bochkareva O. V. Samodova V. V. Sokolovskaya A. A. Girina A. Yu. Kurganskaya E. M. Simovanyan M. A. Kim O. A. Rychkova L. V. Khanipova S. G. Grigorev |
| author_facet | A. A. Vilnits Yu. V. Lobzin N. V. Skripchenko L. N. Mazankova O. I. Klimova A. Yu. Rtishchev I. M. Osmanov K. V. Markova N. H. Tkhakushinova G. P. Martinova A. U. Sabitov R. K. Babik I. Ya. Izvekova V. V. Krasnov E. V. Sidorenkova O. V. Borisova N. M. Bochkareva O. V. Samodova V. V. Sokolovskaya A. A. Girina A. Yu. Kurganskaya E. M. Simovanyan M. A. Kim O. A. Rychkova L. V. Khanipova S. G. Grigorev |
| author_sort | A. A. Vilnits |
| collection | DOAJ |
| description | The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality in invasive forms of the disease, but also with severe consequences in survivors, who are not recorded in our country.The aim of study: to analyze clinical manifestations, complications of the acute period and outcomes of invasive forms of meningococcal disease in children in various regions of the Russian Federation.Materials and methods: an analysis of data from 1327 inpatient medical records of children with an invasive meningococcal infection from 14 regional centers of the Russian Federation for 2012-2021 was carried out (28.3% of cases of the disease in children in the represented federal districts).Results: it was found that young children predominated among the patients – the median was 27.4 (10.7-70.4) months. Complications of the acute period, often combined, were observed in 47.6% of cases. The development of septic shock was noted in 30.4%, Waterhouse-Friderichsen syndrome in 6.6%, carditis in 2.9%, cerebral edema in 15.7%, arthritis in 1.4% of cases; the formation of hydrocephalus, subdural effusion, sensorineural hearing loss in 1.8%, 0.6%, 1% of children, respectively. The presence of soft tissue necrosis requiring surgical intervention was noted in 3.5% of cases. Mortality rate was 10.1%. At the time of discharge from the hospital, 30% of children had complications associated with meningococcal infection: organ dysfunction/ failure in 13.2% of patients (severe in 1.3%), cerebral insufficiency in 19.6%; severe psycho-neurological deficits, sensorineural hearing loss, problems associated with the need for orthopedic/surgical interventions accounted for 0.7%, 0.6% and 0.8%, respectively.Conclusion. Considering the epidemiological features of meningococcal infection – the risk of a sharp increase in morbidity in short periods of time, the life-threatening nature of the disease itself, it is necessary to remain alert to these risks and take all possible measures to prevent the disease using all available means, the most effective of which is vaccine prevention. |
| format | Article |
| id | doaj-art-70e2862ca52a4047a06cf88c3fb11f34 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-70e2862ca52a4047a06cf88c3fb11f342025-08-20T04:00:17ZrusJournal InfectologyЖурнал инфектологии2072-67322024-01-0115451310.22625/2072-6732-2023-15-4-5-131108Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the dayA. A. Vilnits0Yu. V. Lobzin1N. V. Skripchenko2L. N. Mazankova3O. I. Klimova4A. Yu. Rtishchev5I. M. Osmanov6K. V. Markova7N. H. Tkhakushinova8G. P. Martinova9A. U. Sabitov10R. K. Babik11I. Ya. Izvekova12V. V. Krasnov13E. V. Sidorenkova14O. V. Borisova15N. M. Bochkareva16O. V. Samodova17V. V. Sokolovskaya18A. A. Girina19A. Yu. Kurganskaya20E. M. Simovanyan21M. A. Kim22O. A. Rychkova23L. V. Khanipova24S. G. Grigorev25Pediatric Research and Clinical Center for Infectious Disease; Saint-Petersburg State Pediatric Medical UniversityPediatric Research and Clinical Center for Infectious Disease; North-Western State Medical University named after I.I. Mechnikov; Military Medical Academy named after S.M. KirovPediatric Research and Clinical Center for Infectious Disease; Saint-Petersburg State Pediatric Medical UniversityRussian Medical Academy of Continuing Professional EducationRussian Medical Academy of Continuing Professional Education; Children’s City Clinical Hospital named after Z.A. BashlyaevaRussian National Research Medical University named after N.I. PirogovChildren’s City Clinical Hospital named after Z.A. BashlyaevaPediatric Research and Clinical Center for Infectious DiseaseKuban State Medical University; Specialized Clinical Children’s Infectious HospitalKrasnoyarsk State Medical University named after Professor V.F. Voyno-YasenetskyUral State Medical UniversitySouth Ural State Medical University; Children’s City Clinical Hospital № 8Novosibirsk State Medical UniversityPrivolzhsky Research Medical UniversityInfectious Clinical Hospital № 23Samara State Medical UniversitySamara State Medical UniversityNorthern State Medical UniversitySmolensk State Medical University; Clinical Hospital № 1Khanty-Mansiysk State Medical AcademyDistrict Clinical HospitalRostov State Medical UniversityRostov State Medical UniversityTyumen State Medical UniversityTyumen State Medical UniversityPediatric Research and Clinical Center for Infectious Disease; Saint-Petersburg State Pediatric Medical University; Military Medical Academy named after S.M. KirovThe heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality in invasive forms of the disease, but also with severe consequences in survivors, who are not recorded in our country.The aim of study: to analyze clinical manifestations, complications of the acute period and outcomes of invasive forms of meningococcal disease in children in various regions of the Russian Federation.Materials and methods: an analysis of data from 1327 inpatient medical records of children with an invasive meningococcal infection from 14 regional centers of the Russian Federation for 2012-2021 was carried out (28.3% of cases of the disease in children in the represented federal districts).Results: it was found that young children predominated among the patients – the median was 27.4 (10.7-70.4) months. Complications of the acute period, often combined, were observed in 47.6% of cases. The development of septic shock was noted in 30.4%, Waterhouse-Friderichsen syndrome in 6.6%, carditis in 2.9%, cerebral edema in 15.7%, arthritis in 1.4% of cases; the formation of hydrocephalus, subdural effusion, sensorineural hearing loss in 1.8%, 0.6%, 1% of children, respectively. The presence of soft tissue necrosis requiring surgical intervention was noted in 3.5% of cases. Mortality rate was 10.1%. At the time of discharge from the hospital, 30% of children had complications associated with meningococcal infection: organ dysfunction/ failure in 13.2% of patients (severe in 1.3%), cerebral insufficiency in 19.6%; severe psycho-neurological deficits, sensorineural hearing loss, problems associated with the need for orthopedic/surgical interventions accounted for 0.7%, 0.6% and 0.8%, respectively.Conclusion. Considering the epidemiological features of meningococcal infection – the risk of a sharp increase in morbidity in short periods of time, the life-threatening nature of the disease itself, it is necessary to remain alert to these risks and take all possible measures to prevent the disease using all available means, the most effective of which is vaccine prevention.https://journal.niidi.ru/jofin/article/view/1562meningococcal infectionchildrencomplicationsoutcomes |
| spellingShingle | A. A. Vilnits Yu. V. Lobzin N. V. Skripchenko L. N. Mazankova O. I. Klimova A. Yu. Rtishchev I. M. Osmanov K. V. Markova N. H. Tkhakushinova G. P. Martinova A. U. Sabitov R. K. Babik I. Ya. Izvekova V. V. Krasnov E. V. Sidorenkova O. V. Borisova N. M. Bochkareva O. V. Samodova V. V. Sokolovskaya A. A. Girina A. Yu. Kurganskaya E. M. Simovanyan M. A. Kim O. A. Rychkova L. V. Khanipova S. G. Grigorev Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day Журнал инфектологии meningococcal infection children complications outcomes |
| title | Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day |
| title_full | Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day |
| title_fullStr | Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day |
| title_full_unstemmed | Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day |
| title_short | Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day |
| title_sort | meningococcal infection in children in the period 2012 2021 main results of a retrospective multicenter study issues of the day |
| topic | meningococcal infection children complications outcomes |
| url | https://journal.niidi.ru/jofin/article/view/1562 |
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