Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients
ABSTRACT Background The risk factors and clinical prediction of cardiovascular comorbidities in patients with breast cancer have not been fully clarified. Aims This retrospective case–control study was designed to investigate the factors affecting myocardial ischemia occurrence in breast cancer pati...
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Wiley
2025-07-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70075 |
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| author | Yeyan Lei Dongmei Li Shuang Bai Xing Zeng Rongyuan Yang Qing Liu |
| author_facet | Yeyan Lei Dongmei Li Shuang Bai Xing Zeng Rongyuan Yang Qing Liu |
| author_sort | Yeyan Lei |
| collection | DOAJ |
| description | ABSTRACT Background The risk factors and clinical prediction of cardiovascular comorbidities in patients with breast cancer have not been fully clarified. Aims This retrospective case–control study was designed to investigate the factors affecting myocardial ischemia occurrence in breast cancer patients. Methods and Results A total of 194 cases (144 breast cancer and 50 benign breast tumor patients) were included. Univariate and multivariable Cox regression found that ApoB, age, and HER2 were significant factors responsible for the myocardial ischemia occurrence in breast cancer patients. By comparing the significance of ApoB in breast cancer patients versus benign breast tumor patients, it was observed that ApoB and HER2 were crucial predictors of myocardial ischemia in breast cancer patients compared to those with benign breast tumors. These factors were utilized to construct the clinical prediction model, achieving a combined area under the curve (AUC) of 0.583. The decision curve analysis (DCA) indicated that the model‐predicted population, within a threshold ranging from 0.35 to 0.70, would experience a therapeutically clinical net benefit. Kaplan–Meier plot indicated that ApoBhigh and HER2+ categories were high‐risk populations for myocardial ischemia in breast cancer patients, although there was no significant difference between ApoBlow and ApoBhigh subgroups for the 3‐year disease‐free survival. Conclusion We demonstrated that ApoB and HER2 were potential factors in predicting the myocardial ischemia occurrence in breast cancer patients. This study will help provide clinical evidence for the early prediction of cardiovascular comorbidities in breast cancer patients. |
| format | Article |
| id | doaj-art-70e23dbda4244754a80e47adb152ea42 |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Cancer Reports |
| spelling | doaj-art-70e23dbda4244754a80e47adb152ea422025-08-20T03:34:28ZengWileyCancer Reports2573-83482025-07-0187n/an/a10.1002/cnr2.70075Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer PatientsYeyan Lei0Dongmei Li1Shuang Bai2Xing Zeng3Rongyuan Yang4Qing Liu5Zhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine‐Zhuhai Hospital, the Second Clinical School of Medicine Guangzhou University of Chinese Medicine Zhuhai ChinaZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine‐Zhuhai Hospital, the Second Clinical School of Medicine Guangzhou University of Chinese Medicine Zhuhai ChinaZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine‐Zhuhai Hospital, the Second Clinical School of Medicine Guangzhou University of Chinese Medicine Zhuhai ChinaDepartment of Clinical Medicine The Third Clinical School of Guangzhou Medical University Guangzhou ChinaZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine‐Zhuhai Hospital, the Second Clinical School of Medicine Guangzhou University of Chinese Medicine Zhuhai ChinaZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine‐Zhuhai Hospital, the Second Clinical School of Medicine Guangzhou University of Chinese Medicine Zhuhai ChinaABSTRACT Background The risk factors and clinical prediction of cardiovascular comorbidities in patients with breast cancer have not been fully clarified. Aims This retrospective case–control study was designed to investigate the factors affecting myocardial ischemia occurrence in breast cancer patients. Methods and Results A total of 194 cases (144 breast cancer and 50 benign breast tumor patients) were included. Univariate and multivariable Cox regression found that ApoB, age, and HER2 were significant factors responsible for the myocardial ischemia occurrence in breast cancer patients. By comparing the significance of ApoB in breast cancer patients versus benign breast tumor patients, it was observed that ApoB and HER2 were crucial predictors of myocardial ischemia in breast cancer patients compared to those with benign breast tumors. These factors were utilized to construct the clinical prediction model, achieving a combined area under the curve (AUC) of 0.583. The decision curve analysis (DCA) indicated that the model‐predicted population, within a threshold ranging from 0.35 to 0.70, would experience a therapeutically clinical net benefit. Kaplan–Meier plot indicated that ApoBhigh and HER2+ categories were high‐risk populations for myocardial ischemia in breast cancer patients, although there was no significant difference between ApoBlow and ApoBhigh subgroups for the 3‐year disease‐free survival. Conclusion We demonstrated that ApoB and HER2 were potential factors in predicting the myocardial ischemia occurrence in breast cancer patients. This study will help provide clinical evidence for the early prediction of cardiovascular comorbidities in breast cancer patients.https://doi.org/10.1002/cnr2.70075ApoB and HER2breast cancercase–control studyclinical prediction modelmyocardial ischemia risk |
| spellingShingle | Yeyan Lei Dongmei Li Shuang Bai Xing Zeng Rongyuan Yang Qing Liu Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients Cancer Reports ApoB and HER2 breast cancer case–control study clinical prediction model myocardial ischemia risk |
| title | Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients |
| title_full | Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients |
| title_fullStr | Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients |
| title_full_unstemmed | Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients |
| title_short | Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients |
| title_sort | clinical relationship between serum apob her2 and myocardial ischemia risk in breast cancer patients |
| topic | ApoB and HER2 breast cancer case–control study clinical prediction model myocardial ischemia risk |
| url | https://doi.org/10.1002/cnr2.70075 |
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