A new view of the therapy of osteoarthrosis
The insights into the pathogenesis of osteoarthrosis (OA) are being constantly expanded. A great role in the development of OA is assigned to immune disorders, particularly to proinflammatory cytokines (interleukin-1 — IL-1, tumor necrosis factor-α). Among the proinflammatory mediators, IL-1 is of t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2012-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/455 |
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| Summary: | The insights into the pathogenesis of osteoarthrosis (OA) are being constantly expanded. A great role in the development of OA is assigned to immune disorders, particularly to proinflammatory cytokines (interleukin-1 — IL-1, tumor necrosis factor-α). Among the proinflammatory mediators, IL-1 is of the greatest value. Diacerein that is acetylated derivative of rein is used to inhibit the activity of IL-1 in OA. Nonsteroidal anti-inflammatory drugs, nimesulide in particular, reduce the activity of cytokines to some degree. |
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| ISSN: | 1996-7012 2310-158X |