Dose enhancement of nanogold for prostate radiation: Monte Carlo simulation using the ICRP voxel computational male phantom
Using a male ICRP voxel computational phantom, Monte Carlo simulations were performed to estimate the dose enhancement ratio (DER) in prostate radiation for 6 and 10 MV photon energy. A fully validated linear accelerator head was used, initially with a single beam to calculate the DER for different...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Journal of Taibah University for Science |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2024.2340138 |
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| Summary: | Using a male ICRP voxel computational phantom, Monte Carlo simulations were performed to estimate the dose enhancement ratio (DER) in prostate radiation for 6 and 10 MV photon energy. A fully validated linear accelerator head was used, initially with a single beam to calculate the DER for different concentrations of nanogold mixed with prostate tissue. Each energy was tested with (FF) and without (FFF) a flattening filter. The DER was then calculated for a verified 10 MV treatment plan to mimic the real treatment scenario. The results showed that the DER increased with concentration, especially for FFF mode. In addition, the flattening filter-free enhancement ratio (FFFER) was investigated, from which it was found that a 6 MV FFF with a 40 mg/ml concentration enhanced the dose by a factor of 1.03 compared to 6 MV FF. For the entire plan, the difference between FFF and FF for both energies was approximately 2%. |
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| ISSN: | 1658-3655 |