Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice
Background: Data on the presentation and management of patients with eosinophilic granulomatosis with polyangiitis (EGPA) in private practice are limited. Objective: We sought to characterize the profiles and disease burden of patients with EGPA in a real-world private practice setting. Methods: Thi...
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Elsevier
2025-05-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325000384 |
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| author | Michael E. Wechsler, MD Anna Kovalszki, MD Jared Silver, MD, PhD Brian Stone, MD William McCann, MD Lynn Huynh, MPH, DrPH Anamika Khanal, BA Mingchen Ye, MS Mei Sheng Duh, MPH, ScD Arijita Deb, PhD |
| author_facet | Michael E. Wechsler, MD Anna Kovalszki, MD Jared Silver, MD, PhD Brian Stone, MD William McCann, MD Lynn Huynh, MPH, DrPH Anamika Khanal, BA Mingchen Ye, MS Mei Sheng Duh, MPH, ScD Arijita Deb, PhD |
| author_sort | Michael E. Wechsler, MD |
| collection | DOAJ |
| description | Background: Data on the presentation and management of patients with eosinophilic granulomatosis with polyangiitis (EGPA) in private practice are limited. Objective: We sought to characterize the profiles and disease burden of patients with EGPA in a real-world private practice setting. Methods: This was a retrospective, noninterventional, longitudinal study (GSK ID: 217426) of US Allergy Partners network data. For patients with a diagnosis of EGPA, confirmed by 2 or more EGPA clinical features, index was defined as their first visit with an Allergy Partners physician (January 2007–June 2021); postindex lasted until loss of follow-up or study end (December 2021). Patient characteristics at index, physician characteristics at any time, symptoms, treatment characteristics, and clinical outcomes postindex were assessed. Results: Of 52 patients (median follow-up, 3.7 years), 75% were diagnosed with EGPA outside the Allergy Partners network. Each patient received care from a median (Q1-Q3) of 4.0 (3.0-5.0) physician specialties. Most had asthma (92%), rhinitis (75%), and sinusitis (62%) and experienced a mean ± SD of 18.1 ± 4.3 distinct self-reported symptoms. Most (85%) used oral corticosteroids, with 73% (32 of 44) on daily doses of more than 12 mg; 60% used mepolizumab. Overall, 75% of patients (39 of 52) achieved a response (improved/controlled symptoms); 46% (24 of 52) achieved controlled status after worsened, unchanged, or active symptoms, and of these 38% (9 of 24) relapsed. Conclusions: The complex private practice presentation of EGPA, with heterogeneous patient response to standard treatments, highlights a significant disease burden and continued need for optimized treatment strategies within a multidisciplinary team approach. |
| format | Article |
| id | doaj-art-70cf86f8a88747639cfef7765f99aa23 |
| institution | OA Journals |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
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| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-70cf86f8a88747639cfef7765f99aa232025-08-20T02:28:38ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-05-014210043710.1016/j.jacig.2025.100437Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practiceMichael E. Wechsler, MD0Anna Kovalszki, MD1Jared Silver, MD, PhD2Brian Stone, MD3William McCann, MD4Lynn Huynh, MPH, DrPH5Anamika Khanal, BA6Mingchen Ye, MS7Mei Sheng Duh, MPH, ScD8Arijita Deb, PhD9National Jewish Health, Denver, Colo; Corresponding author: Michael E. Wechsler, MD, National Jewish Health, 1400 Jackson St, Denver, CO 80230.University of Michigan, Ann Arbor, MichUS Medical Affairs–Respiratory, GSK, Durham, NCAllergy Partners of Western North Carolina, Asheville, NCAllergy Partners of Western North Carolina, Asheville, NCAnalysis Group, Boston, MassAnalysis Group, Boston, MassAnalysis Group, Boston, MassAnalysis Group, Boston, MassGlobal Real-World Evidence & Health Outcomes Research, GSK, Philadelphia, PaBackground: Data on the presentation and management of patients with eosinophilic granulomatosis with polyangiitis (EGPA) in private practice are limited. Objective: We sought to characterize the profiles and disease burden of patients with EGPA in a real-world private practice setting. Methods: This was a retrospective, noninterventional, longitudinal study (GSK ID: 217426) of US Allergy Partners network data. For patients with a diagnosis of EGPA, confirmed by 2 or more EGPA clinical features, index was defined as their first visit with an Allergy Partners physician (January 2007–June 2021); postindex lasted until loss of follow-up or study end (December 2021). Patient characteristics at index, physician characteristics at any time, symptoms, treatment characteristics, and clinical outcomes postindex were assessed. Results: Of 52 patients (median follow-up, 3.7 years), 75% were diagnosed with EGPA outside the Allergy Partners network. Each patient received care from a median (Q1-Q3) of 4.0 (3.0-5.0) physician specialties. Most had asthma (92%), rhinitis (75%), and sinusitis (62%) and experienced a mean ± SD of 18.1 ± 4.3 distinct self-reported symptoms. Most (85%) used oral corticosteroids, with 73% (32 of 44) on daily doses of more than 12 mg; 60% used mepolizumab. Overall, 75% of patients (39 of 52) achieved a response (improved/controlled symptoms); 46% (24 of 52) achieved controlled status after worsened, unchanged, or active symptoms, and of these 38% (9 of 24) relapsed. Conclusions: The complex private practice presentation of EGPA, with heterogeneous patient response to standard treatments, highlights a significant disease burden and continued need for optimized treatment strategies within a multidisciplinary team approach.http://www.sciencedirect.com/science/article/pii/S2772829325000384EGPAbiological productsburden of diseaseeosinophiliaprivate practicesymptoms |
| spellingShingle | Michael E. Wechsler, MD Anna Kovalszki, MD Jared Silver, MD, PhD Brian Stone, MD William McCann, MD Lynn Huynh, MPH, DrPH Anamika Khanal, BA Mingchen Ye, MS Mei Sheng Duh, MPH, ScD Arijita Deb, PhD Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice Journal of Allergy and Clinical Immunology: Global EGPA biological products burden of disease eosinophilia private practice symptoms |
| title | Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice |
| title_full | Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice |
| title_fullStr | Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice |
| title_full_unstemmed | Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice |
| title_short | Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice |
| title_sort | eosinophilic granulomatosis with polyangiitis patient profiles from a large us allergy practice |
| topic | EGPA biological products burden of disease eosinophilia private practice symptoms |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325000384 |
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