Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma
In this study, we retrospectively analyzed the clinicopathological features of a case of hepatic infantile hemangioma (HIH) that malignantly transformed into hemangiosarcoma. HIH, a congenital disease, is the most common benign tumor of the liver in children, and its malignant transformation into he...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1614698/full |
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| author | Xiafei Gu Qing Tao Zijian Lu Jianping Liu Zhang Zhang Changli Lu |
| author_facet | Xiafei Gu Qing Tao Zijian Lu Jianping Liu Zhang Zhang Changli Lu |
| author_sort | Xiafei Gu |
| collection | DOAJ |
| description | In this study, we retrospectively analyzed the clinicopathological features of a case of hepatic infantile hemangioma (HIH) that malignantly transformed into hemangiosarcoma. HIH, a congenital disease, is the most common benign tumor of the liver in children, and its malignant transformation into hepatic angiosarcoma (HAS) is rare. HIH expresses markers of vascular origin and specifically expresses glucose transporter protein isoform 1. When the malignant transformation of HAS occurs, the vascular lumens anastomose with each other and form a sieve mesh, with pseudo-papillae and solid areas, heterogeneous proliferation of tumor cells, spindle/or epithelioid morphology, heterogeneous distribution of chromatin, enlarged nuclei, and pathologic karyotypes, with strong diffuse positivity of P53 and P16, increased Ki-67 proliferative activity, suggest malignant transformation of HAS. Imaging is the preferred examination method for HIH; however, the presence or absence of characteristic changes in HAS is unclear. There is no uniform treatment guideline for this type of tumor, and a reasonable individualized treatment plan should be formulated according to the specific conditions of the children. There is a lack of case reports of the malignant transformation of HIH into HAS. It is unclear whether HIH treatment should be still extended, and the prognosis is also unclear; therefore, more case reports are needed to accumulate experience. |
| format | Article |
| id | doaj-art-70ccfe4edc444b0c9ec8a9d4d69e5ebc |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-70ccfe4edc444b0c9ec8a9d4d69e5ebc2025-08-20T05:32:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.16146981614698Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcomaXiafei GuQing TaoZijian LuJianping LiuZhang ZhangChangli LuIn this study, we retrospectively analyzed the clinicopathological features of a case of hepatic infantile hemangioma (HIH) that malignantly transformed into hemangiosarcoma. HIH, a congenital disease, is the most common benign tumor of the liver in children, and its malignant transformation into hepatic angiosarcoma (HAS) is rare. HIH expresses markers of vascular origin and specifically expresses glucose transporter protein isoform 1. When the malignant transformation of HAS occurs, the vascular lumens anastomose with each other and form a sieve mesh, with pseudo-papillae and solid areas, heterogeneous proliferation of tumor cells, spindle/or epithelioid morphology, heterogeneous distribution of chromatin, enlarged nuclei, and pathologic karyotypes, with strong diffuse positivity of P53 and P16, increased Ki-67 proliferative activity, suggest malignant transformation of HAS. Imaging is the preferred examination method for HIH; however, the presence or absence of characteristic changes in HAS is unclear. There is no uniform treatment guideline for this type of tumor, and a reasonable individualized treatment plan should be formulated according to the specific conditions of the children. There is a lack of case reports of the malignant transformation of HIH into HAS. It is unclear whether HIH treatment should be still extended, and the prognosis is also unclear; therefore, more case reports are needed to accumulate experience.https://www.frontiersin.org/articles/10.3389/fonc.2025.1614698/fullliverinfantile hemangiomahemangiosarcomamalignant transformationtumor |
| spellingShingle | Xiafei Gu Qing Tao Zijian Lu Jianping Liu Zhang Zhang Changli Lu Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma Frontiers in Oncology liver infantile hemangioma hemangiosarcoma malignant transformation tumor |
| title | Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma |
| title_full | Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma |
| title_fullStr | Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma |
| title_full_unstemmed | Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma |
| title_short | Case Report: Hepatic infantile hemangioma malignantly transformed into hemangiosarcoma |
| title_sort | case report hepatic infantile hemangioma malignantly transformed into hemangiosarcoma |
| topic | liver infantile hemangioma hemangiosarcoma malignant transformation tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1614698/full |
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