Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation
Influenza vaccination is the most cost-effective strategy for influenza prevention. Influenza vaccines have been found to be effective against symptomatic and medically attended outpatient influenza illnesses. However, there is currently a lack of data regarding the effectiveness of inactivated infl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2376821 |
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| author | Shuang Yang Qing Wang Tingting Li Jiang Long Yu Xiong Luzhao Feng Qing Wang Yong Zhao Jule Yang Wenge Tang Huadong Zhang Li Qi |
| author_facet | Shuang Yang Qing Wang Tingting Li Jiang Long Yu Xiong Luzhao Feng Qing Wang Yong Zhao Jule Yang Wenge Tang Huadong Zhang Li Qi |
| author_sort | Shuang Yang |
| collection | DOAJ |
| description | Influenza vaccination is the most cost-effective strategy for influenza prevention. Influenza vaccines have been found to be effective against symptomatic and medically attended outpatient influenza illnesses. However, there is currently a lack of data regarding the effectiveness of inactivated influenza vaccines in Chongqing, China. We conducted a prospective observational test-negative design study. Outpatient and emergency cases presenting with influenza-like illnesses (ILI) and available influenza reverse transcription polymerase chain reaction (RT-PCR) were selected and classified as cases (positive influenza RT-PCR) or controls (negative influenza RT-PCR). A total of 7,307 cases of influenza and 7,905 control subjects were included in this study. The overall adjusted influenza vaccine effectiveness (IVE) was 44.4% (95% confidence interval (CI): 32.5–54.2%). In the age groups of less than 6 years old, 6–18 years old, and 19–59 years old, the adjusted IVE were 32.2% (95% CI: 10.0–48.9%), 48.2% (95% CI: 30.6–61.4%), and 72.0% (95% CI: 43.6–86.1%). The adjusted IVE for H1N1, H3N2 and B (Victoria) were 71.1% (95% CI: 55.4–81.3%), 36.1% (95% CI: 14.6–52.2%) and 33.7% (95% CI: 14.6–48.5%). Influenza vaccination was effective in Chongqing from 2018 to 2022. Evaluating IVE in this area is feasible and should be conducted annually in the future. |
| format | Article |
| id | doaj-art-70cc40e319304615a63cc1f4c2b79ffc |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-70cc40e319304615a63cc1f4c2b79ffc2025-08-20T02:16:46ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2376821Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluationShuang Yang0Qing Wang1Tingting Li2Jiang Long3Yu Xiong4Luzhao Feng5Qing Wang6Yong Zhao7Jule Yang8Wenge Tang9Huadong Zhang10Li Qi11Infectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSchool of Public Health, Chongqing Medical University, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfectious Disease Prevention and Control, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, ChinaInfluenza vaccination is the most cost-effective strategy for influenza prevention. Influenza vaccines have been found to be effective against symptomatic and medically attended outpatient influenza illnesses. However, there is currently a lack of data regarding the effectiveness of inactivated influenza vaccines in Chongqing, China. We conducted a prospective observational test-negative design study. Outpatient and emergency cases presenting with influenza-like illnesses (ILI) and available influenza reverse transcription polymerase chain reaction (RT-PCR) were selected and classified as cases (positive influenza RT-PCR) or controls (negative influenza RT-PCR). A total of 7,307 cases of influenza and 7,905 control subjects were included in this study. The overall adjusted influenza vaccine effectiveness (IVE) was 44.4% (95% confidence interval (CI): 32.5–54.2%). In the age groups of less than 6 years old, 6–18 years old, and 19–59 years old, the adjusted IVE were 32.2% (95% CI: 10.0–48.9%), 48.2% (95% CI: 30.6–61.4%), and 72.0% (95% CI: 43.6–86.1%). The adjusted IVE for H1N1, H3N2 and B (Victoria) were 71.1% (95% CI: 55.4–81.3%), 36.1% (95% CI: 14.6–52.2%) and 33.7% (95% CI: 14.6–48.5%). Influenza vaccination was effective in Chongqing from 2018 to 2022. Evaluating IVE in this area is feasible and should be conducted annually in the future.https://www.tandfonline.com/doi/10.1080/21645515.2024.2376821Influenzavaccine effectivenesspublic healthcase controltest-negative study |
| spellingShingle | Shuang Yang Qing Wang Tingting Li Jiang Long Yu Xiong Luzhao Feng Qing Wang Yong Zhao Jule Yang Wenge Tang Huadong Zhang Li Qi Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation Human Vaccines & Immunotherapeutics Influenza vaccine effectiveness public health case control test-negative study |
| title | Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation |
| title_full | Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation |
| title_fullStr | Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation |
| title_full_unstemmed | Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation |
| title_short | Effectiveness of influenza vaccine among the population in Chongqing, China, 2018–2022: A test negative design-based evaluation |
| title_sort | effectiveness of influenza vaccine among the population in chongqing china 2018 2022 a test negative design based evaluation |
| topic | Influenza vaccine effectiveness public health case control test-negative study |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2376821 |
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