Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population
Objective: This study aimed to explore the relationship between serum fibroblast growth factor 21 (FGF21) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), and further explore the mediation effect of inflammation in their association. Methods: This study included 1,710 com...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2025-08-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/14/8/EC-25-0351.xml |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849406988285378560 |
|---|---|
| author | Hongyu Tan Tingting Hu Yunhui Pan Yiting Xu Yufei Wang Xiaojing Ma Yuqian Bao |
| author_facet | Hongyu Tan Tingting Hu Yunhui Pan Yiting Xu Yufei Wang Xiaojing Ma Yuqian Bao |
| author_sort | Hongyu Tan |
| collection | DOAJ |
| description | Objective: This study aimed to explore the relationship between serum fibroblast growth factor 21 (FGF21) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), and further explore the mediation effect of inflammation in their association. Methods: This study included 1,710 community residents, including 697 men and 1,013 women, with a median age of 59 (55–63) years. Abdominal ultrasound was used to detect the liver and calculate liver fat content (LFC). MASLD was diagnosed according to the 2023 Delphi consensus. Serum FGF21 levels were measured using enzyme-linked immunosorbent assay. Inflammation levels were assessed through C-reactive protein (CRP), white blood cells (WBCs), and tumor necrosis factor-α (TNF-α). Results: Regardless of overweight/obese status, serum FGF21 levels were higher in individuals with MASLD than in individuals without MASLD (all P < 0.05). In the multivariate logistic regression model, for every 1-unit increase in serum FGF21 levels, the risk of MASLD was 1.46 (95% confidence interval (CI), 1.11–1.92) and 1.51 (95% CI, 1.19–1.93) in lean and overweight/obesity subjects, respectively. Moreover, serum FGF21 levels were positively correlated with LFC (P < 0.05), and the relationship between serum FGF21 and LFC could be partially mediated by CRP, WBC, and TNF-α. Conclusions: Regardless of overweight/obese status, serum FGF21 levels were significantly associated with an elevated risk of MASLD. Furthermore, serum FGF21 levels were independently associated with LFC, which could be partially mediated by inflammation. |
| format | Article |
| id | doaj-art-70cb04d8f82a49a1b81bc117efc4cc25 |
| institution | Kabale University |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj-art-70cb04d8f82a49a1b81bc117efc4cc252025-08-20T03:36:13ZengBioscientificaEndocrine Connections2049-36142025-08-0114810.1530/EC-25-03511Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based populationHongyu Tan0Tingting Hu1Yunhui Pan2Yiting Xu3Yufei Wang4Xiaojing Ma5Yuqian Bao6Jinzhou Medical University Graduate Training Base, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai, ChinaJinzhou Medical University Graduate Training Base, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective: This study aimed to explore the relationship between serum fibroblast growth factor 21 (FGF21) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), and further explore the mediation effect of inflammation in their association. Methods: This study included 1,710 community residents, including 697 men and 1,013 women, with a median age of 59 (55–63) years. Abdominal ultrasound was used to detect the liver and calculate liver fat content (LFC). MASLD was diagnosed according to the 2023 Delphi consensus. Serum FGF21 levels were measured using enzyme-linked immunosorbent assay. Inflammation levels were assessed through C-reactive protein (CRP), white blood cells (WBCs), and tumor necrosis factor-α (TNF-α). Results: Regardless of overweight/obese status, serum FGF21 levels were higher in individuals with MASLD than in individuals without MASLD (all P < 0.05). In the multivariate logistic regression model, for every 1-unit increase in serum FGF21 levels, the risk of MASLD was 1.46 (95% confidence interval (CI), 1.11–1.92) and 1.51 (95% CI, 1.19–1.93) in lean and overweight/obesity subjects, respectively. Moreover, serum FGF21 levels were positively correlated with LFC (P < 0.05), and the relationship between serum FGF21 and LFC could be partially mediated by CRP, WBC, and TNF-α. Conclusions: Regardless of overweight/obese status, serum FGF21 levels were significantly associated with an elevated risk of MASLD. Furthermore, serum FGF21 levels were independently associated with LFC, which could be partially mediated by inflammation.https://ec.bioscientifica.com/view/journals/ec/14/8/EC-25-0351.xmlfibroblast growth factor 21metabolic dysfunction-associated steatotic liver diseaseinflammationliver fat content |
| spellingShingle | Hongyu Tan Tingting Hu Yunhui Pan Yiting Xu Yufei Wang Xiaojing Ma Yuqian Bao Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population Endocrine Connections fibroblast growth factor 21 metabolic dysfunction-associated steatotic liver disease inflammation liver fat content |
| title | Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population |
| title_full | Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population |
| title_fullStr | Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population |
| title_full_unstemmed | Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population |
| title_short | Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population |
| title_sort | associations among serum fgf21 levels inflammation and metabolic dysfunction associated steatotic liver disease mediation analyses in a chinese community based population |
| topic | fibroblast growth factor 21 metabolic dysfunction-associated steatotic liver disease inflammation liver fat content |
| url | https://ec.bioscientifica.com/view/journals/ec/14/8/EC-25-0351.xml |
| work_keys_str_mv | AT hongyutan associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation AT tingtinghu associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation AT yunhuipan associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation AT yitingxu associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation AT yufeiwang associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation AT xiaojingma associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation AT yuqianbao associationsamongserumfgf21levelsinflammationandmetabolicdysfunctionassociatedsteatoticliverdiseasemediationanalysesinachinesecommunitybasedpopulation |