Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers

Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers

Abstract Global elimination of hepatitis C virus (HCV) will require an effective cross-genotype vaccine. The HCV E2 envelope glycoprotein is the main target of neutralizing antibodies but also contains epitopes that elicit non-neutralizing antibodies which may provide protection through Fc effector...

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Main Authors: Salman Shahid, Sharanbasappa S. Karade, S. Saif Hasan, Rui Yin, Liqun Jiang, Yanxin Liu, Nathaniel Felbinger, Liudmila Kulakova, Eric A. Toth, Zhen-Yong Keck, Steven K. H. Foung, Thomas R. Fuerst, Brian G. Pierce, Roy A. Mariuzza
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08239-w
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