Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy
Abstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is h...
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Wiley
2024-11-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202405741 |
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| author | Ruxi Deng Chunrong Ren Xinran Song Wuyang Wei Hai Wang Quanyu Nie Ying Liu Pan Li Li Ding Meiqi Chang Yu Chen Yang Zhou |
| author_facet | Ruxi Deng Chunrong Ren Xinran Song Wuyang Wei Hai Wang Quanyu Nie Ying Liu Pan Li Li Ding Meiqi Chang Yu Chen Yang Zhou |
| author_sort | Ruxi Deng |
| collection | DOAJ |
| description | Abstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is hindered by the long distance of charge migration from the bulk to the material surface. Herein, atomically thin Bi2O2(OH)(NO3) (AT‐BON) nanosheets are rationally engineered through disrupting the weaker hydrogen bonds within the [OH] and [NO3] layer in the bulk material. The ultrathin structure of AT‐BON piezocatalytic nanosheets shortens the migration distance of carriers, expands the specific surface area, and accelerates the charge transfer efficiency, showcasing a natural advantage in ROS generation. Importantly, the non‐centrosymmetric polar crystal structure grants the nanosheets the ability to separate electron‐hole pairs. Under ultrasonic mechanical stress, Bi2O2(OH)(NO3) nanosheets with the remarkable piezoelectric feature exhibit the desirable in vivo antineoplastic outcomes in both breast cancer model and liver cancer model. Especially, the AT‐BON‐induced ROS bursts lead to the activation of the Caspase‐1‐driven pyroptosis pathway. This study highlights the beneficial impact of bulk material thinning on enhancing ROS generation efficiency and anti‐cancer effects. |
| format | Article |
| id | doaj-art-70c7f227ff82478a9a7cafbbbc902b9d |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-70c7f227ff82478a9a7cafbbbc902b9d2025-08-20T02:58:41ZengWileyAdvanced Science2198-38442024-11-011142n/an/a10.1002/advs.202405741Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer TherapyRuxi Deng0Chunrong Ren1Xinran Song2Wuyang Wei3Hai Wang4Quanyu Nie5Ying Liu6Pan Li7Li Ding8Meiqi Chang9Yu Chen10Yang Zhou11Department of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaDepartment of Gastroenterology The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaDepartment of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaDepartment of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaDepartment of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaDepartment of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaDepartment of Ultrasound Chongqing Key Laboratory of Ultrasound Molecular Imaging the Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 P. R. ChinaDepartment of Medical Ultrasound National Clinical Research Center of Interventional Medicine Shanghai Tenth People's Hospital Tongji University Cancer Center School of Medicine Tongji University Shanghai 200072 P. R. ChinaLaboratory Center Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200071 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaDepartment of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. ChinaAbstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is hindered by the long distance of charge migration from the bulk to the material surface. Herein, atomically thin Bi2O2(OH)(NO3) (AT‐BON) nanosheets are rationally engineered through disrupting the weaker hydrogen bonds within the [OH] and [NO3] layer in the bulk material. The ultrathin structure of AT‐BON piezocatalytic nanosheets shortens the migration distance of carriers, expands the specific surface area, and accelerates the charge transfer efficiency, showcasing a natural advantage in ROS generation. Importantly, the non‐centrosymmetric polar crystal structure grants the nanosheets the ability to separate electron‐hole pairs. Under ultrasonic mechanical stress, Bi2O2(OH)(NO3) nanosheets with the remarkable piezoelectric feature exhibit the desirable in vivo antineoplastic outcomes in both breast cancer model and liver cancer model. Especially, the AT‐BON‐induced ROS bursts lead to the activation of the Caspase‐1‐driven pyroptosis pathway. This study highlights the beneficial impact of bulk material thinning on enhancing ROS generation efficiency and anti‐cancer effects.https://doi.org/10.1002/advs.202405741Bi2O2(OH)(NO3) nanosheetspyroptosissonopiezocatalytic therapyultrasoundultrathin |
| spellingShingle | Ruxi Deng Chunrong Ren Xinran Song Wuyang Wei Hai Wang Quanyu Nie Ying Liu Pan Li Li Ding Meiqi Chang Yu Chen Yang Zhou Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy Advanced Science Bi2O2(OH)(NO3) nanosheets pyroptosis sonopiezocatalytic therapy ultrasound ultrathin |
| title | Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy |
| title_full | Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy |
| title_fullStr | Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy |
| title_full_unstemmed | Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy |
| title_short | Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy |
| title_sort | two dimensional atomically thin piezoelectric nanosheets for efficient pyroptosis dominated sonopiezoelectric cancer therapy |
| topic | Bi2O2(OH)(NO3) nanosheets pyroptosis sonopiezocatalytic therapy ultrasound ultrathin |
| url | https://doi.org/10.1002/advs.202405741 |
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