Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy

Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy

Abstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is h...

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Bibliographic Details
Main Authors: Ruxi Deng, Chunrong Ren, Xinran Song, Wuyang Wei, Hai Wang, Quanyu Nie, Ying Liu, Pan Li, Li Ding, Meiqi Chang, Yu Chen, Yang Zhou
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
Bi2O2(OH)(NO3) nanosheets
pyroptosis
sonopiezocatalytic therapy
ultrasound
ultrathin
Online Access:https://doi.org/10.1002/advs.202405741
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Summary:Abstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is hindered by the long distance of charge migration from the bulk to the material surface. Herein, atomically thin Bi2O2(OH)(NO3) (AT‐BON) nanosheets are rationally engineered through disrupting the weaker hydrogen bonds within the [OH] and [NO3] layer in the bulk material. The ultrathin structure of AT‐BON piezocatalytic nanosheets shortens the migration distance of carriers, expands the specific surface area, and accelerates the charge transfer efficiency, showcasing a natural advantage in ROS generation. Importantly, the non‐centrosymmetric polar crystal structure grants the nanosheets the ability to separate electron‐hole pairs. Under ultrasonic mechanical stress, Bi2O2(OH)(NO3) nanosheets with the remarkable piezoelectric feature exhibit the desirable in vivo antineoplastic outcomes in both breast cancer model and liver cancer model. Especially, the AT‐BON‐induced ROS bursts lead to the activation of the Caspase‐1‐driven pyroptosis pathway. This study highlights the beneficial impact of bulk material thinning on enhancing ROS generation efficiency and anti‐cancer effects.
ISSN:2198-3844

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