Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference
Abstract The Breast Cancer UK—Breast Cancer Prevention Conference addressed risk from environmental pollutants and health behaviour‐related breast‐cancer risk. Epidemiological studies examining individual chemicals and breast cancer risk have produced inconclusive results including endocrine disrupt...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-09-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.70255 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849716344009785344 |
|---|---|
| author | Britta Stordal Michelle Harvie Michael N. Antoniou Michelle Bellingham Doris S. M. Chan Philippa Darbre Oskar Karlsson Andreas Kortenkamp Pamela Magee Stefano Mandriota Elisabete Silva James E. Turner Laura N. Vandenberg D. Gareth Evans |
| author_facet | Britta Stordal Michelle Harvie Michael N. Antoniou Michelle Bellingham Doris S. M. Chan Philippa Darbre Oskar Karlsson Andreas Kortenkamp Pamela Magee Stefano Mandriota Elisabete Silva James E. Turner Laura N. Vandenberg D. Gareth Evans |
| author_sort | Britta Stordal |
| collection | DOAJ |
| description | Abstract The Breast Cancer UK—Breast Cancer Prevention Conference addressed risk from environmental pollutants and health behaviour‐related breast‐cancer risk. Epidemiological studies examining individual chemicals and breast cancer risk have produced inconclusive results including endocrine disrupting chemicals (EDCs) Bisphenol A, per‐ and polyfluorinated alkyl substances as well as aluminium. However, laboratory studies have shown that multiple EDCs, can work together to exhibit effects, even when combined at levels that alone are ineffective. The TEXB‐α/β assay measures total estrogenic load, and studies have provided evidence of a link between multiple‐chemical exposures and breast cancer. However, prospective studies using TEXB‐α/β are needed to establish a causative link. There is also a need to assess real‐life exposure to environmental‐chemical mixtures during pregnancy, and their potential involvement in programming adverse foetal health outcomes in later life. Higher rates of breast cancer have occurred alongside increases in potentially‐modifiable risk factors such as obesity. Increasing body‐mass index is associated with increased risk of developing postmenopausal breast cancer, but with decreased risk of premenopausal breast cancer. In contrast, lower rates of breast cancer in Asian compared to Western populations have been linked to soya/isoflavone consumption. Risk is decreased by breastfeeding, which is in addition to the decrease in risk observed for each birth and a young first‐birth. Risk is lower in those with higher levels of self‐reported physical activity. Current evidence suggests breast‐cancer survivors should also avoid weight gain, be physically active, and eat a healthy diet for overall health. A broad scientific perspective on breast cancer risk requires focus on both environmental exposure to chemicals and health behaviour‐related risk. Research into chemical exposure needs to focus on chemical mixtures and prospective epidemiological studies in order to test the effects on breast cancer risk. Behaviour‐related research needs to focus on implementation as well as deeper understanding of the mechanisms of cancer prevention. |
| format | Article |
| id | doaj-art-70c3e2894184461e82f75d07e3fce5a2 |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-70c3e2894184461e82f75d07e3fce5a22025-08-20T03:13:01ZengWileyCancer Medicine2045-76342024-09-011318n/an/a10.1002/cam4.70255Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention ConferenceBritta Stordal0Michelle Harvie1Michael N. Antoniou2Michelle Bellingham3Doris S. M. Chan4Philippa Darbre5Oskar Karlsson6Andreas Kortenkamp7Pamela Magee8Stefano Mandriota9Elisabete Silva10James E. Turner11Laura N. Vandenberg12D. Gareth Evans13Department of Natural Sciences Middlesex University London, The Burroughs Hendon London UKManchester University Hospital Foundation NHS Trust Manchester UKGene Expression and Therapy Group, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics King's College London London UKSchool of Biodiversity, One Health and Veterinary Medicine College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow UKDepartment of Epidemiology and Biostatistics, School of Public Health Imperial College London London UKSchool of Biological Sciences University of Reading Reading UKScience for Life Laboratory, Department of Environmental Science Stockholm University Stockholm SwedenCentre for Pollution Research and Policy, Department of Life Sciences College of Health, Medicine and Life Sciences, Brunel University London Uxbridge UKNutrition Innovation Centre for Food & Health (NICHE) Ulster University Coleraine UKLaboratoire de Cancérogenèse Environnementale, Fondation des Grangettes Chêne‐Bougeries SwitzerlandCentre for Pollution Research and Policy, Department of Life Sciences College of Health, Medicine and Life Sciences, Brunel University London Uxbridge UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKDepartment of Environmental Health Sciences, School of Public Health and Health Sciences University of Massachusetts Amherst Amherst Massachusetts USADivision of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UKAbstract The Breast Cancer UK—Breast Cancer Prevention Conference addressed risk from environmental pollutants and health behaviour‐related breast‐cancer risk. Epidemiological studies examining individual chemicals and breast cancer risk have produced inconclusive results including endocrine disrupting chemicals (EDCs) Bisphenol A, per‐ and polyfluorinated alkyl substances as well as aluminium. However, laboratory studies have shown that multiple EDCs, can work together to exhibit effects, even when combined at levels that alone are ineffective. The TEXB‐α/β assay measures total estrogenic load, and studies have provided evidence of a link between multiple‐chemical exposures and breast cancer. However, prospective studies using TEXB‐α/β are needed to establish a causative link. There is also a need to assess real‐life exposure to environmental‐chemical mixtures during pregnancy, and their potential involvement in programming adverse foetal health outcomes in later life. Higher rates of breast cancer have occurred alongside increases in potentially‐modifiable risk factors such as obesity. Increasing body‐mass index is associated with increased risk of developing postmenopausal breast cancer, but with decreased risk of premenopausal breast cancer. In contrast, lower rates of breast cancer in Asian compared to Western populations have been linked to soya/isoflavone consumption. Risk is decreased by breastfeeding, which is in addition to the decrease in risk observed for each birth and a young first‐birth. Risk is lower in those with higher levels of self‐reported physical activity. Current evidence suggests breast‐cancer survivors should also avoid weight gain, be physically active, and eat a healthy diet for overall health. A broad scientific perspective on breast cancer risk requires focus on both environmental exposure to chemicals and health behaviour‐related risk. Research into chemical exposure needs to focus on chemical mixtures and prospective epidemiological studies in order to test the effects on breast cancer risk. Behaviour‐related research needs to focus on implementation as well as deeper understanding of the mechanisms of cancer prevention.https://doi.org/10.1002/cam4.70255aluminiumbreast cancerbreastfeedingendocrine disrupting chemicalsepidemiologyexercise |
| spellingShingle | Britta Stordal Michelle Harvie Michael N. Antoniou Michelle Bellingham Doris S. M. Chan Philippa Darbre Oskar Karlsson Andreas Kortenkamp Pamela Magee Stefano Mandriota Elisabete Silva James E. Turner Laura N. Vandenberg D. Gareth Evans Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference Cancer Medicine aluminium breast cancer breastfeeding endocrine disrupting chemicals epidemiology exercise |
| title | Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference |
| title_full | Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference |
| title_fullStr | Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference |
| title_full_unstemmed | Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference |
| title_short | Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference |
| title_sort | breast cancer risk and prevention in 2024 an overview from the breast cancer uk breast cancer prevention conference |
| topic | aluminium breast cancer breastfeeding endocrine disrupting chemicals epidemiology exercise |
| url | https://doi.org/10.1002/cam4.70255 |
| work_keys_str_mv | AT brittastordal breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT michelleharvie breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT michaelnantoniou breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT michellebellingham breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT dorissmchan breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT philippadarbre breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT oskarkarlsson breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT andreaskortenkamp breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT pamelamagee breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT stefanomandriota breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT elisabetesilva breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT jameseturner breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT lauranvandenberg breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference AT dgarethevans breastcancerriskandpreventionin2024anoverviewfromthebreastcancerukbreastcancerpreventionconference |