Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity

Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic plasticity, anxiety, neurodegeneration, etc. In the peripheral nervo...

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Bibliographic Details
Main Authors:	Timur A. Khasanov, Ekaterina E. Maleeva, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Sergey A. Kozlov, Yaroslav A. Andreev, Dmitry I. Osmakov
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Series:	Marine Drugs
Subjects:	acid-sensing ion channel peptide ligand mutagenesis molecular docking pain models analgesic effect
Online Access:	https://www.mdpi.com/1660-3397/22/9/382
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Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity

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