Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis
The review analyzes literature data and the results of our own research on the role of reactive nitrogen species (NO, NO2, N2O3) in the initiation and progression of tumors. The possibility of modulating the activity of inducible NO synthase by the biologically active components of plant products an...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-04-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/203 |
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| author | V. P. Deryagina V. P. Reutov |
| author_facet | V. P. Deryagina V. P. Reutov |
| author_sort | V. P. Deryagina |
| collection | DOAJ |
| description | The review analyzes literature data and the results of our own research on the role of reactive nitrogen species (NO, NO2, N2O3) in the initiation and progression of tumors. The possibility of modulating the activity of inducible NO synthase by the biologically active components of plant products and their effect on carcinogenesis is analyzed. Possible mechanisms of the ambiguous action of NO and its metabolic products in the mechanisms of carcinogenesis are discussed. The generalization and analysis of these data allowed us to formulate some principles for the use of substances that modulate the activity of inducible NO synthase and affect the formation of NO and its metabolic products in inhibiting carcinogenesis. |
| format | Article |
| id | doaj-art-70bc3e771d0f4cf4a5abc5c58139ece9 |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-70bc3e771d0f4cf4a5abc5c58139ece92025-08-20T03:00:55ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-04-0161183610.17650/2313-805X-2019-6-1-18-36152Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesisV. P. Deryagina0V. P. Reutov1N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaInstitute of Higher Nervous Activity and Neurophysiology of the Russian Academy of SciencesThe review analyzes literature data and the results of our own research on the role of reactive nitrogen species (NO, NO2, N2O3) in the initiation and progression of tumors. The possibility of modulating the activity of inducible NO synthase by the biologically active components of plant products and their effect on carcinogenesis is analyzed. Possible mechanisms of the ambiguous action of NO and its metabolic products in the mechanisms of carcinogenesis are discussed. The generalization and analysis of these data allowed us to formulate some principles for the use of substances that modulate the activity of inducible NO synthase and affect the formation of NO and its metabolic products in inhibiting carcinogenesis.https://umo.abvpress.ru/jour/article/view/203nitric oxideactive forms of nitric oxideinducible no-synthasecycle of nitric oxidecarcinogenesisbiologically active component of plant products |
| spellingShingle | V. P. Deryagina V. P. Reutov Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis Успехи молекулярной онкологии nitric oxide active forms of nitric oxide inducible no-synthase cycle of nitric oxide carcinogenesis biologically active component of plant products |
| title | Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis |
| title_full | Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis |
| title_fullStr | Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis |
| title_full_unstemmed | Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis |
| title_short | Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis |
| title_sort | modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis |
| topic | nitric oxide active forms of nitric oxide inducible no-synthase cycle of nitric oxide carcinogenesis biologically active component of plant products |
| url | https://umo.abvpress.ru/jour/article/view/203 |
| work_keys_str_mv | AT vpderyagina modulationoftheformationofactiveformsofnitrogenbyingredientsofplantproductsintheinhibitionofcarcinogenesis AT vpreutov modulationoftheformationofactiveformsofnitrogenbyingredientsofplantproductsintheinhibitionofcarcinogenesis |