Staphylococci in high resolution: Capturing diversity within the human nasal microbiota

Staphylococci in high resolution: Capturing diversity within the human nasal microbiota

Summary: Staphylococci include both nasal commensals and opportunistic pathogens, globally responsible for a large proportion of infection-related deaths, especially in S. aureus carriers. To understand staphylococcal temporal dynamics within the nasal microbiota, we employed Staphylococcus-targeted...

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Main Authors: Anna Cäcilia Ingham, Duncan Y.K. Ng, Søren Iversen, Cindy M. Liu, Khoa Manh Dinh, Silva Holtfreter, Sofie Marie Edslev, Thor Bech Johannesen, Amalie Katrine Rendboe, Mette Theilgaard Christiansen, Kim Lee Ng, Robert Skov, Stefanie Samietz, Dörte Radke, Stefan Weiss, Uwe Völker, Barbara M. Bröker, Lise Tornvig Erikstrup, Christian Erikstrup, Lance B. Price, Paal Skytt Andersen, Marc Stegger
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006254
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Summary:Summary: Staphylococci include both nasal commensals and opportunistic pathogens, globally responsible for a large proportion of infection-related deaths, especially in S. aureus carriers. To understand staphylococcal temporal dynamics within the nasal microbiota, we employed Staphylococcus-targeted sequencing in two cohorts from Denmark and Germany. We identified two major staphylococcal community state types (sCSTs)—one dominated by S. aureus and one dominated by S. epidermidis—and eight subgroups defined by co-colonizing coagulase-negative staphylococci. The distribution of sCSTs was similar between the two cohorts. Predominance of either S. aureus or S. epidermidis was highly persistent over time, whereas co-colonizing staphylococcal species were transient with varying stability among the sCST subgroups. Detection of S. aureus by culture was positively associated with absolute abundance by qPCR. S. aureus domination was diminished when Dolosigranulum and Corynebacterium co-occurred. Our findings could inform efforts to reduce S. aureus nasal colonization and infection.
ISSN:2211-1247

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