Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling
We report the synthesis of germanyl triazoles formed via a copper-catalysed azide–alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2024-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.20.265 |
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| author | John M. Halford-McGuff Thomas M. Richardson Aidan P. McKay Frederik Peschke Glenn A. Burley Allan J. B. Watson |
| author_facet | John M. Halford-McGuff Thomas M. Richardson Aidan P. McKay Frederik Peschke Glenn A. Burley Allan J. B. Watson |
| author_sort | John M. Halford-McGuff |
| collection | DOAJ |
| description | We report the synthesis of germanyl triazoles formed via a copper-catalysed azide–alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species. |
| format | Article |
| id | doaj-art-70aeffa2069f4dd7ad0aeffc6cbd1c79 |
| institution | Kabale University |
| issn | 1860-5397 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-70aeffa2069f4dd7ad0aeffc6cbd1c792025-01-06T12:27:36ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972024-12-012013198320410.3762/bjoc.20.2651860-5397-20-265Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-couplingJohn M. Halford-McGuff0Thomas M. Richardson1Aidan P. McKay2Frederik Peschke3Glenn A. Burley4Allan J. B. Watson5EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK We report the synthesis of germanyl triazoles formed via a copper-catalysed azide–alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.https://doi.org/10.3762/bjoc.20.265chemoselectivityclick chemistrycoppergermaniumtriazole |
| spellingShingle | John M. Halford-McGuff Thomas M. Richardson Aidan P. McKay Frederik Peschke Glenn A. Burley Allan J. B. Watson Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling Beilstein Journal of Organic Chemistry chemoselectivity click chemistry copper germanium triazole |
| title | Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling |
| title_full | Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling |
| title_fullStr | Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling |
| title_full_unstemmed | Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling |
| title_short | Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling |
| title_sort | germanyl triazoles as a platform for cuaac diversification and chemoselective orthogonal cross coupling |
| topic | chemoselectivity click chemistry copper germanium triazole |
| url | https://doi.org/10.3762/bjoc.20.265 |
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