PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis

Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role...

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Main Authors: Lina Sabatino, Alessandra Fucci, Massimo Pancione, Vittorio Colantuoni
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2012/687492
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author Lina Sabatino
Alessandra Fucci
Massimo Pancione
Vittorio Colantuoni
author_facet Lina Sabatino
Alessandra Fucci
Massimo Pancione
Vittorio Colantuoni
author_sort Lina Sabatino
collection DOAJ
description Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination. Epigenetics adds a further layer of complexity to gene regulation in several biological processes. In cancer, the relationship with epigenetic modifications has provided important insights into the underlying molecular mechanisms. These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis. In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development. The role that epigenetic mechanisms play is also addressed disclosing novel crosstalks between PPARG signaling and the epigenetic machinery and suggesting how this dysregulation may contribute to colon cancer development.
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institution Kabale University
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spelling doaj-art-70a85d6cb908414daf77b2f58c8d82122025-02-03T01:10:00ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/687492687492PPARG Epigenetic Deregulation and Its Role in Colorectal TumorigenesisLina Sabatino0Alessandra Fucci1Massimo Pancione2Vittorio Colantuoni3Department of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyPeroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination. Epigenetics adds a further layer of complexity to gene regulation in several biological processes. In cancer, the relationship with epigenetic modifications has provided important insights into the underlying molecular mechanisms. These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis. In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development. The role that epigenetic mechanisms play is also addressed disclosing novel crosstalks between PPARG signaling and the epigenetic machinery and suggesting how this dysregulation may contribute to colon cancer development.http://dx.doi.org/10.1155/2012/687492
spellingShingle Lina Sabatino
Alessandra Fucci
Massimo Pancione
Vittorio Colantuoni
PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
PPAR Research
title PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
title_full PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
title_fullStr PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
title_full_unstemmed PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
title_short PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
title_sort pparg epigenetic deregulation and its role in colorectal tumorigenesis
url http://dx.doi.org/10.1155/2012/687492
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AT vittoriocolantuoni ppargepigeneticderegulationanditsroleincolorectaltumorigenesis