PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/687492 |
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| _version_ | 1832564891480752128 |
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| author | Lina Sabatino Alessandra Fucci Massimo Pancione Vittorio Colantuoni |
| author_facet | Lina Sabatino Alessandra Fucci Massimo Pancione Vittorio Colantuoni |
| author_sort | Lina Sabatino |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination. Epigenetics adds a further layer of complexity to gene regulation in several biological processes. In cancer, the relationship with epigenetic modifications has provided important insights into the underlying molecular mechanisms. These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis. In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development. The role that epigenetic mechanisms play is also addressed disclosing novel crosstalks between PPARG signaling and the epigenetic machinery and suggesting how this dysregulation may contribute to colon cancer development. |
| format | Article |
| id | doaj-art-70a85d6cb908414daf77b2f58c8d8212 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-70a85d6cb908414daf77b2f58c8d82122025-02-03T01:10:00ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/687492687492PPARG Epigenetic Deregulation and Its Role in Colorectal TumorigenesisLina Sabatino0Alessandra Fucci1Massimo Pancione2Vittorio Colantuoni3Department of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, ItalyPeroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination. Epigenetics adds a further layer of complexity to gene regulation in several biological processes. In cancer, the relationship with epigenetic modifications has provided important insights into the underlying molecular mechanisms. These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis. In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development. The role that epigenetic mechanisms play is also addressed disclosing novel crosstalks between PPARG signaling and the epigenetic machinery and suggesting how this dysregulation may contribute to colon cancer development.http://dx.doi.org/10.1155/2012/687492 |
| spellingShingle | Lina Sabatino Alessandra Fucci Massimo Pancione Vittorio Colantuoni PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis PPAR Research |
| title | PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis |
| title_full | PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis |
| title_fullStr | PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis |
| title_full_unstemmed | PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis |
| title_short | PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis |
| title_sort | pparg epigenetic deregulation and its role in colorectal tumorigenesis |
| url | http://dx.doi.org/10.1155/2012/687492 |
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