Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study.
Smoking cessation reduces the cardiovascular risk but increases body weight. We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40...
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235276&type=printable |
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| author | Jung-Hwan Cho Hye-Mi Kwon Se-Eun Park Jin-Hyung Jung Kyung-Do Han Yong-Gyu Park Yang-Hyun Kim Eun-Jung Rhee Won-Young Lee Won-Young Lee |
| author_facet | Jung-Hwan Cho Hye-Mi Kwon Se-Eun Park Jin-Hyung Jung Kyung-Do Han Yong-Gyu Park Yang-Hyun Kim Eun-Jung Rhee Won-Young Lee Won-Young Lee |
| author_sort | Jung-Hwan Cho |
| collection | DOAJ |
| description | Smoking cessation reduces the cardiovascular risk but increases body weight. We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40 years who participated in national health screenings between 2009 and 2010. Subjects who quit smoking were classified into three subgroups according to the weight change between baseline and 4 years prior. Myocardial infarctions and ischemic strokes were followed until the end of 2015. We compared the hazard ratios among smoking cessation subgroups, non-smokers, and current smokers. The mean changes in weight (1.5 ± 3.9 kg) of the smoking cessation group were higher than those of the other groups (p < 0.0001). A total of 31,277 and 46,811 subjects were newly diagnosed with myocardial infarction and ischemic stroke, respectively. Regardless of weight change, all subgroups of smoking cessation had significantly less risk than current smokers. The subgroup of smoking cessation with weight gain over 4kg showed the lowest risk for myocardial infarctions (hazard ratio 0.646, 95% confidence interval 0.583-0.714, p < 0.0001) and ischemic strokes (hazard ratio 0.648, 95% confidence interval 0.591-0.71, p < 0.0001) after multivariable adjustment. In conclusion, weight gain after smoking cessation did not adversely affect the cardiovascular protective effect. |
| format | Article |
| id | doaj-art-70a6622527e24a3da093145d85cfc8a6 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-70a6622527e24a3da093145d85cfc8a62025-08-20T02:10:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023527610.1371/journal.pone.0235276Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study.Jung-Hwan ChoHye-Mi KwonSe-Eun ParkJin-Hyung JungKyung-Do HanYong-Gyu ParkYang-Hyun KimEun-Jung RheeWon-Young LeeWon-Young LeeSmoking cessation reduces the cardiovascular risk but increases body weight. We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40 years who participated in national health screenings between 2009 and 2010. Subjects who quit smoking were classified into three subgroups according to the weight change between baseline and 4 years prior. Myocardial infarctions and ischemic strokes were followed until the end of 2015. We compared the hazard ratios among smoking cessation subgroups, non-smokers, and current smokers. The mean changes in weight (1.5 ± 3.9 kg) of the smoking cessation group were higher than those of the other groups (p < 0.0001). A total of 31,277 and 46,811 subjects were newly diagnosed with myocardial infarction and ischemic stroke, respectively. Regardless of weight change, all subgroups of smoking cessation had significantly less risk than current smokers. The subgroup of smoking cessation with weight gain over 4kg showed the lowest risk for myocardial infarctions (hazard ratio 0.646, 95% confidence interval 0.583-0.714, p < 0.0001) and ischemic strokes (hazard ratio 0.648, 95% confidence interval 0.591-0.71, p < 0.0001) after multivariable adjustment. In conclusion, weight gain after smoking cessation did not adversely affect the cardiovascular protective effect.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235276&type=printable |
| spellingShingle | Jung-Hwan Cho Hye-Mi Kwon Se-Eun Park Jin-Hyung Jung Kyung-Do Han Yong-Gyu Park Yang-Hyun Kim Eun-Jung Rhee Won-Young Lee Won-Young Lee Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study. PLoS ONE |
| title | Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study. |
| title_full | Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study. |
| title_fullStr | Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study. |
| title_full_unstemmed | Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study. |
| title_short | Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study. |
| title_sort | protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain a nationwide cohort study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235276&type=printable |
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